Advances in bioreactor control for production of biotherapeutic products

Advanced control strategies are well established in chemical, pharmaceutical, and food processing industries. Over the past decade, the application of these strategies is being explored for control of bioreactors for manufacturing of biotherapeutics. Most of the industrial bioreactor control strateg...

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Bibliographic Details
Published in:Biotechnology and bioengineering 2023-05, Vol.120 (5), p.1189-1214
Main Authors: Nikita, Saxena, Mishra, Somesh, Gupta, Keshari, Runkana, Venkataramana, Gomes, James, Rathore, Anurag S.
Format: Article
Language:English
Subjects:
Biological activity
bioreactor control
Bioreactors
Control systems
Control systems design
data analytics
Food industry
Food processing
Food processing industry
Industrial applications
Internet of Things
Internet of things (IoT)
process analytical technology (PAT)
Process control
Process controls
Process intensification
process monitoring
Reproducibility of Results
Robust control
Sensors
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Summary:Advanced control strategies are well established in chemical, pharmaceutical, and food processing industries. Over the past decade, the application of these strategies is being explored for control of bioreactors for manufacturing of biotherapeutics. Most of the industrial bioreactor control strategies apply classical control techniques, with the control system designed for the facility at hand. However, with the recent progress in sensors, machinery, and industrial internet of things, and advancements in deeper understanding of the biological processes, coupled with the requirement of flexible production, the need to develop a robust and advanced process control system that can ease process intensification has emerged. This has further fuelled the development of advanced monitoring approaches, modeling techniques, process analytical technologies, and soft sensors. It is seen that proper application of these concepts can significantly improve bioreactor process performance, productivity, and reproducibility. This review is on the recent advancements in bioreactor control and its related aspects along with the associated challenges. This study also offers an insight into the future prospects for development of control strategies that can be designed for industrial‐scale production of biotherapeutic products.
ISSN:0006-3592
1097-0290
DOI:10.1002/bit.28346