Solvato‐Controlled Assembly and Structural Transformation of Emissive Poly‐NHC‐Based Organometallic Cages and Their Applications in Amino Acid Sensing and Fluorescence Imaging

Stimuli‐induced structural transformation of supramolecular cages has drawn increasing attention because of their sensitive feature to external variations as model systems to simulate biological processes. However, combining structural transformation and useful functions has remained a difficult tas...

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Bibliographic Details
Published in:Chemistry : a European journal 2023-04, Vol.29 (23), p.e202300209-n/a
Main Authors: Zhang, Heng, Li, Yang, Zhang, Yi‐Fan, Qiao, Xiu‐Juan, Sun, Li‐Ying, Li, Jianli, Wang, Yao‐Yu, Han, Ying‐Feng
Format: Article
Language:English
Subjects:
Amino acids
applications
Aqueous solutions
Biological activity
Cages
Chemistry
Chemoreception
Fluorescence
Genetic transformation
N-heterocyclic carbene
organometallic cages
Self-assembly
structural transformation
Thermochromism
Topology
Transformations
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Summary:Stimuli‐induced structural transformation of supramolecular cages has drawn increasing attention because of their sensitive feature to external variations as model systems to simulate biological processes. However, combining structural transformation and useful functions has remained a difficult task. This study reports the solvato‐controlled self‐assembly of two unique topologies with different emission characteristics, a water‐soluble Ag8L4 cage (A) and an Ag4L2 cage (B), produced from the same sulfonate‐pendant tetraphenylethene (TPE) bridged tetrakis‐(1,2,4‐triazolium) ligand. Both cages show interesting solvent‐responsive reversible structural transformation, and the change of fluorescence signals can efficiently track the process. Additionally, water‐soluble cage A exhibits unique properties in thermochromism, thiol amino acid sensing, and subcellular imaging in aqueous media. Solvato‐controlled self‐assembly gives a water‐soluble Ag8L4 cage (A) and an Ag4L2 cage (B) produced from the same sulfonate‐pendant tetraphenylethene (TPE) bridged tetrakis‐(1,2,4‐triazolium) ligand. Both cages show interesting solvent‐responsive reversible structural transformations that can be tracked with fluorescence. Furthermore, cage A shows unique properties in thermochromism, thiol amino acid detecting, and subcellular imaging in aqueous media.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202300209