Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer

The importance of mitochondria is not only limited to energy generation but also in several physical and chemical processes critical for cell survival. Mitochondria play an essential role in cellular apoptosis, calcium ion transport and cellular metabolism. Mutation in the nuclear and mitochondrial...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2023-04, Vol.160, p.114398-114398, Article 114398
Main Authors: Mukherjee, Soumi, Bhatti, Gurjit Kaur, Chhabra, Ravindresh, Reddy, P. Hemachandra, Bhatti, Jasvinder Singh
Format: Article
Language:English
Subjects:
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis, Autophagy
Cancer chemoresistance
Drug Resistance, Neoplasm
Humans
Mitochondria - metabolism
Mitochondrial biogenesis, Stemness
Mitochondrial dynamics
Mitochondrial dysfunction
Mitophagy
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - metabolism
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Summary:The importance of mitochondria is not only limited to energy generation but also in several physical and chemical processes critical for cell survival. Mitochondria play an essential role in cellular apoptosis, calcium ion transport and cellular metabolism. Mutation in the nuclear and mitochondrial genes, altered oncogenes/tumor suppressor genes, and deregulated signalling for cell viability are major reasons for cancer progression and chemoresistance. The development of drug resistance in cancer patients is a major challenge in cancer treatment as the resistant cells are often more aggressive. The drug resistant cells of numerous cancer types exhibit the deregulation of mitochondrial function. The increased biogenesis of mitochondria and its dynamic alteration contribute to developing resistance. Further, a small subpopulation of cancer stem cells in the heterogeneous tumor is primarily responsible for chemoresistance and has an attribute of mitochondrial dysfunction. This review highlights the critical role of mitochondrial dysfunction in chemoresistance in cancer cells through the processes of apoptosis, autophagy/mitophagy, and cancer stemness. Mitochondria-targeted therapeutic strategies might help reduce cancer progression and chemoresistance induced by various cancer drugs.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2023.114398