Relationship between the severity of olfactory dysfunction and serum zinc levels

Purpose Although the association between zinc deficiency and olfactory dysfunction is inconclusive, zinc deficiency causes apoptosis of the olfactory ensheathing cells which is involved in olfactory nerve turnover and axon regeneration, thereby suggesting a possible relationship. We investigated the...

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Published in:European archives of oto-rhino-laryngology 2023-07, Vol.280 (7), p.3229-3236
Main Authors: Tanaka, Hirotaka, Mori, Eri, Sekine, Rumi, Yonezawa, Nagomi, Tei, Masayoshi, Otori, Nobuyoshi
Format: Article
Language:English
Subjects:
Axons
Head and Neck Surgery
Humans
Malnutrition
Medicine
Medicine & Public Health
Nerve Regeneration
Neurosurgery
Olfaction Disorders - diagnosis
Olfaction Disorders - etiology
Otorhinolaryngology
Rhinology
Smell - physiology
Zinc
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Summary:Purpose Although the association between zinc deficiency and olfactory dysfunction is inconclusive, zinc deficiency causes apoptosis of the olfactory ensheathing cells which is involved in olfactory nerve turnover and axon regeneration, thereby suggesting a possible relationship. We investigated the relationship between serum zinc levels and olfactory function in patients with olfactory dysfunction. Methods Ninety patients who had been diagnosed with post-infectious, posttraumatic, drug-induced, neurological and idiopathic olfactory dysfunction were included. Patients were divided into zinc normal group and zinc deficiency groups according to three reference values for serum zinc levels (60, 65, 70 µg/dL). The results of olfactory tests and patient backgrounds were used to compare the differences between the two groups. Results There were significantly worse detection and recognition thresholds in the T&T olfactometer and Open Essence (odor identification test) results in the zinc deficiency group (
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-023-07828-x