Butyrate: More Than a Short Chain Fatty Acid

Purpose of Review The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus o...

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Bibliographic Details
Published in:Current nutrition reports 2023-06, Vol.12 (2), p.255-262
Main Authors: Mohamed Elfadil, Osman, Mundi, Manpreet S., Abdelmagid, Marwa G., Patel, Ankitaben, Patel, Nishant, Martindale, Robert
Format: Article
Language:English
Subjects:
Cardiology
Clinical Nutrition
Critical Care
Diabetes
Health Promotion and Disease Prevention
Invited Commentary
Lifestyle Medicine
Medicine
Medicine & Public Health
Oncology
Topical Collection on Gastroenterology
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Summary:Purpose of Review The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus of microbiome understanding. This brief review aims to describe butyrate’s relation to certain biological concepts and their clinical application. Recent Findings Butyrate has reportedly been described as a potent pro-resolution molecule that has a significant role in maintaining gut immunity, supporting gut barrier function, regulation of histone deacetylase (HDAC), and numerous systemic roles. Further research is needed to explore potential benefits of adding SCFAs for patients receiving total parenteral nutrition. Summary Butyrate plays several biological roles in intestinal epithelium anti-inflammatory pathways with clear benefits in numerous acute and chronic disease states and overall human health helping to maintain homeostasis.
ISSN:2161-3311
2161-3311
DOI:10.1007/s13668-023-00461-4