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Butyrate: More Than a Short Chain Fatty Acid
Purpose of Review The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus o...
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| Published in: | Current nutrition reports 2023-06, Vol.12 (2), p.255-262 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c347t-ddf5ddcc0853fe449e20279d33e2c3b3d8f111f38d9e1f7ca9fe50dea415e273 |
| container_end_page | 262 |
| container_issue | 2 |
| container_start_page | 255 |
| container_title | Current nutrition reports |
| container_volume | 12 |
| creator | Mohamed Elfadil, Osman Mundi, Manpreet S. Abdelmagid, Marwa G. Patel, Ankitaben Patel, Nishant Martindale, Robert |
| description | Purpose of Review
The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus of microbiome understanding. This brief review aims to describe butyrate’s relation to certain biological concepts and their clinical application.
Recent Findings
Butyrate has reportedly been described as a potent pro-resolution molecule that has a significant role in maintaining gut immunity, supporting gut barrier function, regulation of histone deacetylase (HDAC), and numerous systemic roles. Further research is needed to explore potential benefits of adding SCFAs for patients receiving total parenteral nutrition.
Summary
Butyrate plays several biological roles in intestinal epithelium anti-inflammatory pathways with clear benefits in numerous acute and chronic disease states and overall human health helping to maintain homeostasis. |
| doi_str_mv | 10.1007/s13668-023-00461-4 |
| format | article |
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The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus of microbiome understanding. This brief review aims to describe butyrate’s relation to certain biological concepts and their clinical application.
Recent Findings
Butyrate has reportedly been described as a potent pro-resolution molecule that has a significant role in maintaining gut immunity, supporting gut barrier function, regulation of histone deacetylase (HDAC), and numerous systemic roles. Further research is needed to explore potential benefits of adding SCFAs for patients receiving total parenteral nutrition.
Summary
Butyrate plays several biological roles in intestinal epithelium anti-inflammatory pathways with clear benefits in numerous acute and chronic disease states and overall human health helping to maintain homeostasis.</description><identifier>ISSN: 2161-3311</identifier><identifier>EISSN: 2161-3311</identifier><identifier>DOI: 10.1007/s13668-023-00461-4</identifier><identifier>PMID: 36763294</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cardiology ; Clinical Nutrition ; Critical Care ; Diabetes ; Health Promotion and Disease Prevention ; Invited Commentary ; Lifestyle Medicine ; Medicine ; Medicine & Public Health ; Oncology ; Topical Collection on Gastroenterology</subject><ispartof>Current nutrition reports, 2023-06, Vol.12 (2), p.255-262</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-ddf5ddcc0853fe449e20279d33e2c3b3d8f111f38d9e1f7ca9fe50dea415e273</citedby><cites>FETCH-LOGICAL-c347t-ddf5ddcc0853fe449e20279d33e2c3b3d8f111f38d9e1f7ca9fe50dea415e273</cites><orcidid>0000-0003-0240-6453</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36763294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohamed Elfadil, Osman</creatorcontrib><creatorcontrib>Mundi, Manpreet S.</creatorcontrib><creatorcontrib>Abdelmagid, Marwa G.</creatorcontrib><creatorcontrib>Patel, Ankitaben</creatorcontrib><creatorcontrib>Patel, Nishant</creatorcontrib><creatorcontrib>Martindale, Robert</creatorcontrib><title>Butyrate: More Than a Short Chain Fatty Acid</title><title>Current nutrition reports</title><addtitle>Curr Nutr Rep</addtitle><addtitle>Curr Nutr Rep</addtitle><description>Purpose of Review
The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus of microbiome understanding. This brief review aims to describe butyrate’s relation to certain biological concepts and their clinical application.
Recent Findings
Butyrate has reportedly been described as a potent pro-resolution molecule that has a significant role in maintaining gut immunity, supporting gut barrier function, regulation of histone deacetylase (HDAC), and numerous systemic roles. Further research is needed to explore potential benefits of adding SCFAs for patients receiving total parenteral nutrition.
Summary
Butyrate plays several biological roles in intestinal epithelium anti-inflammatory pathways with clear benefits in numerous acute and chronic disease states and overall human health helping to maintain homeostasis.</description><subject>Cardiology</subject><subject>Clinical Nutrition</subject><subject>Critical Care</subject><subject>Diabetes</subject><subject>Health Promotion and Disease Prevention</subject><subject>Invited Commentary</subject><subject>Lifestyle Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Topical Collection on Gastroenterology</subject><issn>2161-3311</issn><issn>2161-3311</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kDFPwzAQhS0EohX0DzCgjAwEbJ9jJ2ylooBUxEB3y7XPtFWbFDsZ-u8xpCAmbrkn3XtPuo-QC0ZvGKXqNjKQsswph5xSIVkujsiQsyQAGDv-owdkFOOappGUSYBTMgCpJPBKDMn1fdfug2nxLntpAmbzpakzk70tm9Bmk6VZ1dnUtO0-G9uVOycn3mwijg77jMynD_PJUz57fXyejGe5BaHa3DlfOGctLQvwKESFnHJVOQDkFhbgSs8Y81C6CplX1lQeC-rQCFYgV3BGrvraXWg-Ooyt3q6ixc3G1Nh0UXOlCslBVpCsvLfa0MQY0OtdWG1N2GtG9Rcn3XPSiZP-5qRFCl0e-rvFFt1v5IdKMkBviOlUv2PQ66YLdXr5v9pPPnJwyw</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Mohamed Elfadil, Osman</creator><creator>Mundi, Manpreet S.</creator><creator>Abdelmagid, Marwa G.</creator><creator>Patel, Ankitaben</creator><creator>Patel, Nishant</creator><creator>Martindale, Robert</creator><general>Springer US</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0240-6453</orcidid></search><sort><creationdate>20230601</creationdate><title>Butyrate: More Than a Short Chain Fatty Acid</title><author>Mohamed Elfadil, Osman ; Mundi, Manpreet S. ; Abdelmagid, Marwa G. ; Patel, Ankitaben ; Patel, Nishant ; Martindale, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-ddf5ddcc0853fe449e20279d33e2c3b3d8f111f38d9e1f7ca9fe50dea415e273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiology</topic><topic>Clinical Nutrition</topic><topic>Critical Care</topic><topic>Diabetes</topic><topic>Health Promotion and Disease Prevention</topic><topic>Invited Commentary</topic><topic>Lifestyle Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Topical Collection on Gastroenterology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed Elfadil, Osman</creatorcontrib><creatorcontrib>Mundi, Manpreet S.</creatorcontrib><creatorcontrib>Abdelmagid, Marwa G.</creatorcontrib><creatorcontrib>Patel, Ankitaben</creatorcontrib><creatorcontrib>Patel, Nishant</creatorcontrib><creatorcontrib>Martindale, Robert</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current nutrition reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed Elfadil, Osman</au><au>Mundi, Manpreet S.</au><au>Abdelmagid, Marwa G.</au><au>Patel, Ankitaben</au><au>Patel, Nishant</au><au>Martindale, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Butyrate: More Than a Short Chain Fatty Acid</atitle><jtitle>Current nutrition reports</jtitle><stitle>Curr Nutr Rep</stitle><addtitle>Curr Nutr Rep</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>12</volume><issue>2</issue><spage>255</spage><epage>262</epage><pages>255-262</pages><issn>2161-3311</issn><eissn>2161-3311</eissn><abstract>Purpose of Review
The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus of microbiome understanding. This brief review aims to describe butyrate’s relation to certain biological concepts and their clinical application.
Recent Findings
Butyrate has reportedly been described as a potent pro-resolution molecule that has a significant role in maintaining gut immunity, supporting gut barrier function, regulation of histone deacetylase (HDAC), and numerous systemic roles. Further research is needed to explore potential benefits of adding SCFAs for patients receiving total parenteral nutrition.
Summary
Butyrate plays several biological roles in intestinal epithelium anti-inflammatory pathways with clear benefits in numerous acute and chronic disease states and overall human health helping to maintain homeostasis.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36763294</pmid><doi>10.1007/s13668-023-00461-4</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0240-6453</orcidid></addata></record> |
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| identifier | ISSN: 2161-3311 |
| ispartof | Current nutrition reports, 2023-06, Vol.12 (2), p.255-262 |
| issn | 2161-3311 2161-3311 |
| language | eng |
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| source | Springer Nature |
| subjects | Cardiology Clinical Nutrition Critical Care Diabetes Health Promotion and Disease Prevention Invited Commentary Lifestyle Medicine Medicine Medicine & Public Health Oncology Topical Collection on Gastroenterology |
| title | Butyrate: More Than a Short Chain Fatty Acid |
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