Usefulness of skeletal muscle measurement by computed tomography in patients with esophageal cancer: changes in skeletal muscle mass due to neoadjuvant therapy and the effect on the prognosis

Purpose This analysis was performed to clarify the usefulness of skeletal muscle measurements using computed tomography (CT) in patients with esophageal cancer and the effect of treatment-induced changes in the skeletal muscle mass on the prognosis. Methods Ninety-seven male patients who underwent t...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2023-06, Vol.53 (6), p.692-701
Main Authors: Yamamoto, Miho, Ozawa, Soji, Koyanagi, Kazuo, Kazuno, Akihito, Ninomiya, Yamato, Yatabe, Kentaro, Higuchi, Tadashi, Kanamori, Kohei, Tajima, Kohei
Format: Article
Language:English
Subjects:
Esophageal Neoplasms - diagnostic imaging
Esophageal Neoplasms - pathology
Esophageal Neoplasms - therapy
Esophageal Squamous Cell Carcinoma - pathology
Humans
Male
Medicine
Medicine & Public Health
Muscle, Skeletal - diagnostic imaging
Muscle, Skeletal - pathology
Neoadjuvant Therapy
Neoplasm Recurrence, Local - pathology
Original Article
Prognosis
Retrospective Studies
Sarcopenia - diagnostic imaging
Sarcopenia - etiology
Sarcopenia - pathology
Surgery
Surgical Oncology
Tomography, X-Ray Computed
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Summary:Purpose This analysis was performed to clarify the usefulness of skeletal muscle measurements using computed tomography (CT) in patients with esophageal cancer and the effect of treatment-induced changes in the skeletal muscle mass on the prognosis. Methods Ninety-seven male patients who underwent thoracoscopic esophagectomy for esophageal squamous cell carcinoma were included in the study. The preoperative CT images were analyzed retrospectively. Results In a survival analysis performed according to the preoperative data of skeletal muscle, the low-skeletal muscle index (l-SMI) group had a poorer outcome than the normal skeletal muscle index (n-SMI) group in terms of both the overall survival (OS) and the relapse-free survival (RFS) (OS: P  
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-023-02657-1