Loading…
Usefulness of skeletal muscle measurement by computed tomography in patients with esophageal cancer: changes in skeletal muscle mass due to neoadjuvant therapy and the effect on the prognosis
Purpose This analysis was performed to clarify the usefulness of skeletal muscle measurements using computed tomography (CT) in patients with esophageal cancer and the effect of treatment-induced changes in the skeletal muscle mass on the prognosis. Methods Ninety-seven male patients who underwent t...
Saved in:
| Published in: | Surgery today (Tokyo, Japan) Japan), 2023-06, Vol.53 (6), p.692-701 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c371t-f94db399e59904cc120060ffbb70553d646b9c23eead81419f964f9394cdb04b3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c371t-f94db399e59904cc120060ffbb70553d646b9c23eead81419f964f9394cdb04b3 |
| container_end_page | 701 |
| container_issue | 6 |
| container_start_page | 692 |
| container_title | Surgery today (Tokyo, Japan) |
| container_volume | 53 |
| creator | Yamamoto, Miho Ozawa, Soji Koyanagi, Kazuo Kazuno, Akihito Ninomiya, Yamato Yatabe, Kentaro Higuchi, Tadashi Kanamori, Kohei Tajima, Kohei |
| description | Purpose
This analysis was performed to clarify the usefulness of skeletal muscle measurements using computed tomography (CT) in patients with esophageal cancer and the effect of treatment-induced changes in the skeletal muscle mass on the prognosis.
Methods
Ninety-seven male patients who underwent thoracoscopic esophagectomy for esophageal squamous cell carcinoma were included in the study. The preoperative CT images were analyzed retrospectively.
Results
In a survival analysis performed according to the preoperative data of skeletal muscle, the low-skeletal muscle index (l-SMI) group had a poorer outcome than the normal skeletal muscle index (n-SMI) group in terms of both the overall survival (OS) and the relapse-free survival (RFS) (OS:
P
|
| doi_str_mv | 10.1007/s00595-023-02657-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2775623894</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2775623894</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-f94db399e59904cc120060ffbb70553d646b9c23eead81419f964f9394cdb04b3</originalsourceid><addsrcrecordid>eNp9kc1u3CAUhVHVqJkmfYEuKpbdOAWD7aG7Kkp_pEjZJGuE8WXsqQ0uFxrN0_XVymTSbip1gQDdc7_D5RDylrMrzlj3ARlrVFOxWpTVNl3FX5ANl6Kt6i0XL8mGKckrXit-Tl4j7hmr5ZaxV-RctF0ruJAb8usBweXZAyINjuJ3mCGZmS4Z7Qx0AYM5wgI-0f5AbVjWnGCgKSxhF806Hujk6WrSVBRIH6c0UsCwjmYHhWKNtxA_UjsavwM8av9xMMV5yFCQ1EMwwz7_NMUtjVD4B2r8cDxTcA5sosE_3dYYdj7ghJfkzJkZ4c3zfkEePt_cX3-tbu--fLv-dFtZ0fFUOSWHXigFjVJMWstrxlrmXN93rGnE0Mq2V7YWAGbYcsmVU610Sihph57JXlyQ9yducf6RAZNeJrQwz6Y8OqOuu65pa7FVskjrk9TGgBjB6TVOi4kHzZk-BqdPwekSnH4KTvPS9O6Zn_sFhr8tf5IqAnESYCmVz4x6H3L0Zeb_YX8DTu2o0A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2775623894</pqid></control><display><type>article</type><title>Usefulness of skeletal muscle measurement by computed tomography in patients with esophageal cancer: changes in skeletal muscle mass due to neoadjuvant therapy and the effect on the prognosis</title><source>Springer Nature</source><creator>Yamamoto, Miho ; Ozawa, Soji ; Koyanagi, Kazuo ; Kazuno, Akihito ; Ninomiya, Yamato ; Yatabe, Kentaro ; Higuchi, Tadashi ; Kanamori, Kohei ; Tajima, Kohei</creator><creatorcontrib>Yamamoto, Miho ; Ozawa, Soji ; Koyanagi, Kazuo ; Kazuno, Akihito ; Ninomiya, Yamato ; Yatabe, Kentaro ; Higuchi, Tadashi ; Kanamori, Kohei ; Tajima, Kohei</creatorcontrib><description>Purpose
This analysis was performed to clarify the usefulness of skeletal muscle measurements using computed tomography (CT) in patients with esophageal cancer and the effect of treatment-induced changes in the skeletal muscle mass on the prognosis.
Methods
Ninety-seven male patients who underwent thoracoscopic esophagectomy for esophageal squamous cell carcinoma were included in the study. The preoperative CT images were analyzed retrospectively.
Results
In a survival analysis performed according to the preoperative data of skeletal muscle, the low-skeletal muscle index (l-SMI) group had a poorer outcome than the normal skeletal muscle index (n-SMI) group in terms of both the overall survival (OS) and the relapse-free survival (RFS) (OS:
P
< 0.01, RFS:
P
= 0.01). In the multivariate analysis for the OS, preoperative l-SMI was an independent predictor (hazard ratio: 3.68, 95% confidence interval 1.32–10.2,
P
= 0.01). In patients who underwent neoadjuvant therapy (NAT), the SMI was significantly reduced after NAT (
P
< 0.01). The preoperative skeletal muscle area on CT was strongly correlated with the results of a bioelectrical impedance analysis (BIA) (
ρ
= 0.77,
P
< 0.01).
Conclusions
A decreased preoperative skeletal muscle mass was associated with a poor outcome. In patients who underwent NAT, the SMI was significantly reduced after NAT. An analysis of the skeletal muscle mass using CT images was found to be useful for providing data that corresponded with BIA data.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-023-02657-1</identifier><identifier>PMID: 36763134</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Esophageal Neoplasms - diagnostic imaging ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - therapy ; Esophageal Squamous Cell Carcinoma - pathology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Muscle, Skeletal - diagnostic imaging ; Muscle, Skeletal - pathology ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local - pathology ; Original Article ; Prognosis ; Retrospective Studies ; Sarcopenia - diagnostic imaging ; Sarcopenia - etiology ; Sarcopenia - pathology ; Surgery ; Surgical Oncology ; Tomography, X-Ray Computed</subject><ispartof>Surgery today (Tokyo, Japan), 2023-06, Vol.53 (6), p.692-701</ispartof><rights>The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-f94db399e59904cc120060ffbb70553d646b9c23eead81419f964f9394cdb04b3</citedby><cites>FETCH-LOGICAL-c371t-f94db399e59904cc120060ffbb70553d646b9c23eead81419f964f9394cdb04b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36763134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Miho</creatorcontrib><creatorcontrib>Ozawa, Soji</creatorcontrib><creatorcontrib>Koyanagi, Kazuo</creatorcontrib><creatorcontrib>Kazuno, Akihito</creatorcontrib><creatorcontrib>Ninomiya, Yamato</creatorcontrib><creatorcontrib>Yatabe, Kentaro</creatorcontrib><creatorcontrib>Higuchi, Tadashi</creatorcontrib><creatorcontrib>Kanamori, Kohei</creatorcontrib><creatorcontrib>Tajima, Kohei</creatorcontrib><title>Usefulness of skeletal muscle measurement by computed tomography in patients with esophageal cancer: changes in skeletal muscle mass due to neoadjuvant therapy and the effect on the prognosis</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose
This analysis was performed to clarify the usefulness of skeletal muscle measurements using computed tomography (CT) in patients with esophageal cancer and the effect of treatment-induced changes in the skeletal muscle mass on the prognosis.
Methods
Ninety-seven male patients who underwent thoracoscopic esophagectomy for esophageal squamous cell carcinoma were included in the study. The preoperative CT images were analyzed retrospectively.
Results
In a survival analysis performed according to the preoperative data of skeletal muscle, the low-skeletal muscle index (l-SMI) group had a poorer outcome than the normal skeletal muscle index (n-SMI) group in terms of both the overall survival (OS) and the relapse-free survival (RFS) (OS:
P
< 0.01, RFS:
P
= 0.01). In the multivariate analysis for the OS, preoperative l-SMI was an independent predictor (hazard ratio: 3.68, 95% confidence interval 1.32–10.2,
P
= 0.01). In patients who underwent neoadjuvant therapy (NAT), the SMI was significantly reduced after NAT (
P
< 0.01). The preoperative skeletal muscle area on CT was strongly correlated with the results of a bioelectrical impedance analysis (BIA) (
ρ
= 0.77,
P
< 0.01).
Conclusions
A decreased preoperative skeletal muscle mass was associated with a poor outcome. In patients who underwent NAT, the SMI was significantly reduced after NAT. An analysis of the skeletal muscle mass using CT images was found to be useful for providing data that corresponded with BIA data.</description><subject>Esophageal Neoplasms - diagnostic imaging</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - therapy</subject><subject>Esophageal Squamous Cell Carcinoma - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscle, Skeletal - pathology</subject><subject>Neoadjuvant Therapy</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sarcopenia - diagnostic imaging</subject><subject>Sarcopenia - etiology</subject><subject>Sarcopenia - pathology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tomography, X-Ray Computed</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u3CAUhVHVqJkmfYEuKpbdOAWD7aG7Kkp_pEjZJGuE8WXsqQ0uFxrN0_XVymTSbip1gQDdc7_D5RDylrMrzlj3ARlrVFOxWpTVNl3FX5ANl6Kt6i0XL8mGKckrXit-Tl4j7hmr5ZaxV-RctF0ruJAb8usBweXZAyINjuJ3mCGZmS4Z7Qx0AYM5wgI-0f5AbVjWnGCgKSxhF806Hujk6WrSVBRIH6c0UsCwjmYHhWKNtxA_UjsavwM8av9xMMV5yFCQ1EMwwz7_NMUtjVD4B2r8cDxTcA5sosE_3dYYdj7ghJfkzJkZ4c3zfkEePt_cX3-tbu--fLv-dFtZ0fFUOSWHXigFjVJMWstrxlrmXN93rGnE0Mq2V7YWAGbYcsmVU610Sihph57JXlyQ9yducf6RAZNeJrQwz6Y8OqOuu65pa7FVskjrk9TGgBjB6TVOi4kHzZk-BqdPwekSnH4KTvPS9O6Zn_sFhr8tf5IqAnESYCmVz4x6H3L0Zeb_YX8DTu2o0A</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Yamamoto, Miho</creator><creator>Ozawa, Soji</creator><creator>Koyanagi, Kazuo</creator><creator>Kazuno, Akihito</creator><creator>Ninomiya, Yamato</creator><creator>Yatabe, Kentaro</creator><creator>Higuchi, Tadashi</creator><creator>Kanamori, Kohei</creator><creator>Tajima, Kohei</creator><general>Springer Nature Singapore</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230601</creationdate><title>Usefulness of skeletal muscle measurement by computed tomography in patients with esophageal cancer: changes in skeletal muscle mass due to neoadjuvant therapy and the effect on the prognosis</title><author>Yamamoto, Miho ; Ozawa, Soji ; Koyanagi, Kazuo ; Kazuno, Akihito ; Ninomiya, Yamato ; Yatabe, Kentaro ; Higuchi, Tadashi ; Kanamori, Kohei ; Tajima, Kohei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-f94db399e59904cc120060ffbb70553d646b9c23eead81419f964f9394cdb04b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Esophageal Neoplasms - diagnostic imaging</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - therapy</topic><topic>Esophageal Squamous Cell Carcinoma - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Muscle, Skeletal - pathology</topic><topic>Neoadjuvant Therapy</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Sarcopenia - diagnostic imaging</topic><topic>Sarcopenia - etiology</topic><topic>Sarcopenia - pathology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Miho</creatorcontrib><creatorcontrib>Ozawa, Soji</creatorcontrib><creatorcontrib>Koyanagi, Kazuo</creatorcontrib><creatorcontrib>Kazuno, Akihito</creatorcontrib><creatorcontrib>Ninomiya, Yamato</creatorcontrib><creatorcontrib>Yatabe, Kentaro</creatorcontrib><creatorcontrib>Higuchi, Tadashi</creatorcontrib><creatorcontrib>Kanamori, Kohei</creatorcontrib><creatorcontrib>Tajima, Kohei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Miho</au><au>Ozawa, Soji</au><au>Koyanagi, Kazuo</au><au>Kazuno, Akihito</au><au>Ninomiya, Yamato</au><au>Yatabe, Kentaro</au><au>Higuchi, Tadashi</au><au>Kanamori, Kohei</au><au>Tajima, Kohei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of skeletal muscle measurement by computed tomography in patients with esophageal cancer: changes in skeletal muscle mass due to neoadjuvant therapy and the effect on the prognosis</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>53</volume><issue>6</issue><spage>692</spage><epage>701</epage><pages>692-701</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Purpose
This analysis was performed to clarify the usefulness of skeletal muscle measurements using computed tomography (CT) in patients with esophageal cancer and the effect of treatment-induced changes in the skeletal muscle mass on the prognosis.
Methods
Ninety-seven male patients who underwent thoracoscopic esophagectomy for esophageal squamous cell carcinoma were included in the study. The preoperative CT images were analyzed retrospectively.
Results
In a survival analysis performed according to the preoperative data of skeletal muscle, the low-skeletal muscle index (l-SMI) group had a poorer outcome than the normal skeletal muscle index (n-SMI) group in terms of both the overall survival (OS) and the relapse-free survival (RFS) (OS:
P
< 0.01, RFS:
P
= 0.01). In the multivariate analysis for the OS, preoperative l-SMI was an independent predictor (hazard ratio: 3.68, 95% confidence interval 1.32–10.2,
P
= 0.01). In patients who underwent neoadjuvant therapy (NAT), the SMI was significantly reduced after NAT (
P
< 0.01). The preoperative skeletal muscle area on CT was strongly correlated with the results of a bioelectrical impedance analysis (BIA) (
ρ
= 0.77,
P
< 0.01).
Conclusions
A decreased preoperative skeletal muscle mass was associated with a poor outcome. In patients who underwent NAT, the SMI was significantly reduced after NAT. An analysis of the skeletal muscle mass using CT images was found to be useful for providing data that corresponded with BIA data.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>36763134</pmid><doi>10.1007/s00595-023-02657-1</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-1291 |
| ispartof | Surgery today (Tokyo, Japan), 2023-06, Vol.53 (6), p.692-701 |
| issn | 0941-1291 1436-2813 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2775623894 |
| source | Springer Nature |
| subjects | Esophageal Neoplasms - diagnostic imaging Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophageal Squamous Cell Carcinoma - pathology Humans Male Medicine Medicine & Public Health Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - pathology Neoadjuvant Therapy Neoplasm Recurrence, Local - pathology Original Article Prognosis Retrospective Studies Sarcopenia - diagnostic imaging Sarcopenia - etiology Sarcopenia - pathology Surgery Surgical Oncology Tomography, X-Ray Computed |
| title | Usefulness of skeletal muscle measurement by computed tomography in patients with esophageal cancer: changes in skeletal muscle mass due to neoadjuvant therapy and the effect on the prognosis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T16%3A40%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Usefulness%20of%20skeletal%20muscle%20measurement%20by%20computed%20tomography%20in%20patients%20with%20esophageal%20cancer:%20changes%20in%20skeletal%20muscle%20mass%20due%20to%20neoadjuvant%20therapy%20and%20the%20effect%20on%20the%20prognosis&rft.jtitle=Surgery%20today%20(Tokyo,%20Japan)&rft.au=Yamamoto,%20Miho&rft.date=2023-06-01&rft.volume=53&rft.issue=6&rft.spage=692&rft.epage=701&rft.pages=692-701&rft.issn=0941-1291&rft.eissn=1436-2813&rft_id=info:doi/10.1007/s00595-023-02657-1&rft_dat=%3Cproquest_cross%3E2775623894%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c371t-f94db399e59904cc120060ffbb70553d646b9c23eead81419f964f9394cdb04b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2775623894&rft_id=info:pmid/36763134&rfr_iscdi=true |