Circulating Proteins and Metabolite Biomarkers in Gastric Cancer: A Systematic Review and Meta-analysis

Gastric cancer (GC) is often diagnosed at an advanced stage and thus patients have a poor prognosis. This implies that early detection of this cancer will improve patient prognosis and survival. This systematic review explored the association of circulating protein and metabolite biomarkers with GC...

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Bibliographic Details
Published in:Archives of medical research 2023-02, Vol.54 (2), p.124-134
Main Authors: Deng, Dawei, Zhang, Yuhan, Zhang, Rongzhi, Yi, Jing, Dong, Jianli, Sha, Liyan, Yan, Meiqin
Format: Article
Language:English
Subjects:
Biomarkers
Cancer risk
Circulating biomarkers
Early detection
Ferritins
Gastric cancer
Helicobacter Infections
Humans
Immunoglobulin G
Iron
Pepsinogen A
Pepsinogen C
Stomach Neoplasms
Transferrins
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Summary:Gastric cancer (GC) is often diagnosed at an advanced stage and thus patients have a poor prognosis. This implies that early detection of this cancer will improve patient prognosis and survival. This systematic review explored the association of circulating protein and metabolite biomarkers with GC development. A literature search was conducted until November 2021 on Medline, Embase, Cochrane library, and Web of Science databases. Studies were included if they assessed circulating proteins and metabolites in blood, urine, or saliva and determined their association with GC risk. Quality of identified studies was determined using the Newcastle-Ottawa scale for cohort studies. Random and fixed effects meta-analyses were performed to calculate pooled odds ratio. A total of 53 studies were included. High levels of anti-Helicobacter pylORi IgG levels, pepsinogen I (PGI)
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2022.12.012