Identification of aminobenzoic acids as selective inhibitors of the N-terminal phosphatase of soluble epoxide hydrolase

ABSTRACT Soluble epoxide hydrolase (EC 3.3.2.10) is a key enzyme in the regulation of inflammation and metabolism, whereas, the role of its N-terminal phosphatase activity (N-phos) has been poorly understood because of a lack of selective inhibitors. Here we report 4-aminobenzoic (Ki 15.3 µm) and 3-...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2023-04, Vol.87 (5), p.511-515
Main Authors: Kihara, Yasuhiro, Nishimura, Erina, Kanai, Chisato, Kitano, Yoshikazu, Suzuki, Eriko, Hasumi, Keiji
Format: Article
Language:English
Subjects:
Aminobenzoates
Enzyme Inhibitors - pharmacology
Epoxide Hydrolases - metabolism
Phosphoric Monoester Hydrolases
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Summary:ABSTRACT Soluble epoxide hydrolase (EC 3.3.2.10) is a key enzyme in the regulation of inflammation and metabolism, whereas, the role of its N-terminal phosphatase activity (N-phos) has been poorly understood because of a lack of selective inhibitors. Here we report 4-aminobenzoic (Ki 15.3 µm) and 3-amino-4-hydroxy benzoic acid (Ki 11.7 µm) as selective competitive inhibitors of N-phos.
ISSN:1347-6947
1347-6947
DOI:10.1093/bbb/zbad016