Prognostic value of alkaline phosphatase and bone-specific alkaline phosphatase in breast cancer: A systematic review and meta-analysis

Numerous studies have reported the clinical value of alkaline phosphatase (ALP) and its bone-specific isoforms (bone-specific alkaline phosphatase (BAP)) in breast cancer. The purpose of this meta-analysis was to summarize the prognostic value of serum ALP and BAP in breast cancer, especially focuse...

Full description

Saved in:
Bibliographic Details
Published in:The International Journal of Biological Markers 2023-03, Vol.38 (1), p.25-36
Main Authors: Jiang, Chengying, Hu, Fangke, Xia, Xiaoqing, Guo, Xiaojing
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Alkaline Phosphatase - analysis
Biomarkers
Bone cancer
Bone Neoplasms - secondary
Breast cancer
Breast Neoplasms - pathology
Female
Humans
Isoforms
Medical prognosis
Meta-analysis
Metastases
Metastasis
Phosphatase
Prognosis
Risk factors
Sensitivity analysis
Survival
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Numerous studies have reported the clinical value of alkaline phosphatase (ALP) and its bone-specific isoforms (bone-specific alkaline phosphatase (BAP)) in breast cancer. The purpose of this meta-analysis was to summarize the prognostic value of serum ALP and BAP in breast cancer, especially focused on bone metastasis and survival. PRISMA guidelines were followed to conduct this review. Observational studies were searched in PubMed, Cochcrane Library and EMBASE to January 1, 2022. Data were extracted to explore the prognostic value of ALP and BAP. The quality of the included studies was assessed and the outcome effects were evaluated. Subgroup and sensitivity analyses were performed to explore the potential sources of heterogeneity. Publication bias was assessed. There was a total of 53 studies with 22,436 patients included. For the primary outcome of survival, high levels of both ALP and BAP were associated with short survival time. The hazard ratio of high ALP level on overall survival was 1.72 (95% CI 1.37, 2.16, P 
ISSN:0393-6155
1724-6008
DOI:10.1177/03936155231154662