Identification of Monomethylmonothioarsonic Acid as the Major Thioarsenical Generated During Extraction Processes for Arsenic Species Analysis

Acid extraction is commonly used to analyze arsenic species in rice. During the extraction process, spiked monomethylarsonic acid (MMA) is often transformed into different compounds. A similar phenomenon is observed in the arsenic speciation analysis of seafood. To identify these compounds, we analy...

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Bibliographic Details
Published in:Marine biotechnology (New York, N.Y.) N.Y.), 2023-10, Vol.25 (5), p.677-682
Main Authors: Matsumoto, Eri, Ito, Shihomi, Nishimura, Tsutomu
Format: Article
Language:English
Subjects:
Acids
Analysis
Arsenic
Arsenic - analysis
Arsenic - chemistry
Arsenic compounds
Arsenicals - analysis
Arsenicals - chemistry
Biomedical and Life Sciences
Biotechnology
Bubbling
Chromatography
Chromatography, High Pressure Liquid - methods
Cytotoxicity
Dimethylarsinic acid
Engineering
Freshwater & Marine Ecology
Gases
Hydrogen
Hydrogen sulfide
Hydrogen sulphide
Identification
Inductively coupled plasma
Laboratories
Life Sciences
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Microbiology
Scientific imaging
Seafood
Seafoods
Speciation
Sulfur
Sulphides
Sulphur
Toxicity
Zoology
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Summary:Acid extraction is commonly used to analyze arsenic species in rice. During the extraction process, spiked monomethylarsonic acid (MMA) is often transformed into different compounds. A similar phenomenon is observed in the arsenic speciation analysis of seafood. To identify these compounds, we analyzed a previously prepared extract using liquid chromatography–time-of-flight/mass spectrometry in differential analysis and liquid chromatography–inductively coupled plasma-MS. The compound was identified as monomethylmonothioarsonic acid (MMMTA), a thioarsenical, which is estimated to be more cytotoxic than MMA. As MMMTA was readily produced by bubbling hydrogen sulfide through MMA, this suggests that MMA reacts with sulfur in rice during the extraction process. Our data also suggested that dimethylarsinic acid could be transformed into another compound, although the generation rate was low. For reliable arsenic speciation analyses, the transformation of arsenic compounds during extraction must be avoided. This study demonstrates that arsenic compounds can be transformed by dilute acid extraction.
ISSN:1436-2228
1436-2236
DOI:10.1007/s10126-023-10200-z