Effects of Flammulina velutipes polysaccharides on gut microbiota composition and metabolism in vitro fermentation

Flammulina velutipes polysaccharides (FVP) exhibit many biological activities, but the effects on gut microflora and metabolism were still unclear. Here, we explored the composition of FVP, their influence on human gut microflora composition and metabolites. FVP were used to vitro fermentation throu...

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Bibliographic Details
Published in:Food science and biotechnology 2023-03, Vol.32 (3), p.361-369
Main Authors: Su, Anxiang, Ma, Gaoxing, Ma, Ning, Pei, Fei, Yang, Wenjian, Hu, Qiuhui
Format: Article
Language:English
Subjects:
Biological activity
Chemistry
Chemistry and Materials Science
Composition
Fatty acids
Fermentation
Flammulina velutipes
Food Science
Galactose
Intestinal microflora
Linoleic acid
Mannose
Metabolism
Metabolites
Metabolomics
Microbiota
Nutrition
Polysaccharides
Research Article
rRNA 16S
Saccharides
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Summary:Flammulina velutipes polysaccharides (FVP) exhibit many biological activities, but the effects on gut microflora and metabolism were still unclear. Here, we explored the composition of FVP, their influence on human gut microflora composition and metabolites. FVP were used to vitro fermentation through human fecal inoculums. In addition, 16S rRNA sequencing were used to assess the effects of FVP on the gut microbiota. The metabolic profiles were investigated using untargeted metabolomics approaches in the LC-MS platform. The results showed that FVP was mainly consisted of glucose, mannose, xylose, fucose and galactose. FVP is shown to increase the relative abundances of Bifidobacteriaceae , as well as Bacteroidaceae and remarkably decrease the numbers of genera Lachnospiraceae coupled with Enterococcaceae . The differential metabolites were identified and mainly involved the metabolism of glycerophospholipid, linoleic acid and synthesis of unsaturated fatty acids. FVP may exhibit biological activity function by regulating gut microflora composition and metabolites.
ISSN:1226-7708
2092-6456
DOI:10.1007/s10068-022-01192-y