Elevated platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with polymyositis/dermatomyositis: a retrospective study

• Published in: Clinical rheumatology 2023-06, Vol.42 (6), p.1615-1624
• Main Authors: Li, Meiqi, Yan, Suyan, Dong, Rongrong, Xiang, Weizhen, Ma, Zhenzhen, Yang, Qingrui
• Format: Article
• Language: English
• Subjects: Dermatomyositis; Dermatomyositis - complications; Humans; Inflammatory diseases; Leukocytes (neutrophilic); Lung diseases; Lung Diseases, Interstitial - etiology; Lymphocytes; Medicine; Medicine & Public Health; Melanoma; Mortality; Neutrophils; Original Article; Platelets; Polymyositis; Prognosis; Retrospective Studies; Rheumatology; Risk factors
• ISSN: 0770-3198; 1434-9949
• DOI: 10.1007/s10067-023-06542-7

Objectives This study aimed to examine the diagnostic and prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in patients with polymyositis/dermatomyositis (PM/DM). Method Clinical data of 200 patients with PM/DM and 204 healthy controls were retrospectively reviewed. We examined whether the PLR and NLR were associated with PM/DM. Results The PLR and NLR were higher in patients with PM/DM than in controls (both P < 0.001). The PLR and NLR were higher in patients with DM than in those with PM (both P < 0.01). The PLR was higher in the anti-melanoma differentiation-associated protein-5 (anti-MDA5) + PM/DM group than in the anti-MDA5 - PM/DM group ( P = 0.002). The NLR in non-survivors was higher than that in survivors ( P = 0.01). The NLR was positively correlated with the occurrence of interstitial lung disease (ILD). The PLR and NLR were independent predictors of PM/DM, as well as risk factors (both P < 0.001). Moreover, the NLR had a predictive value for PM/DM-ILD and was closely related to mortality ( P = 0.033, P = 0.003, respectively). Conclusions Patients with PM/DM have a higher NLR and PLR than healthy controls, especially in those with anti-MDA5 + . The PLR and NLR are independent risk factors for PM/DM and have some predictive value. The NLR is correlated with ILD and associated with an increased risk of mortality in patients with PM/DM. The NLR and PLR may be simple, economical, and accurate diagnostic and prognostic markers for patients with PM/DM. Key points • The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been studied in numerous inflammatory diseases as potential markers, but their clinical significance in polymyositis/dermatomyositis (PM/DM) remains unclear. • We examined the changes in the NLR and PLR between patients with PM/DM and healthy controls, as well as their association with mortality, interstitial lung disease, and anti-melanoma differentiation-associated protein-5. • Patients with PM/DM may benefit from using the NLR and PLR as simple, economical, and accurate diagnostic and prognostic markers.