Neuropeptide diuretic hormone 31 mediates memory and sleep via distinct neural pathways in Drosophila

Memory formation and sleep regulation are critical for brain functions in animals from invertebrates to humans. Neuropeptides play a pivotal role in regulating physiological behaviors, including memory formation and sleep. However, the detailed mechanisms by which neuropeptides regulate these physio...

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Bibliographic Details
Published in:Neuroscience research 2023-07, Vol.192, p.11-25
Main Authors: Lyu, Sizhe, Terao, Noritaka, Nakashima, Hirofumi, Itoh, Motoyuki, Tonoki, Ayako
Format: Article
Language:English
Subjects:
Animals
DH31
Diuretics - metabolism
Drosophila
Drosophila - physiology
Drosophila melanogaster - physiology
Drosophila Proteins - genetics
Fan-shaped body
Hormones - metabolism
Humans
Memory
Neuropeptide
Neuropeptides
Sleep
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Summary:Memory formation and sleep regulation are critical for brain functions in animals from invertebrates to humans. Neuropeptides play a pivotal role in regulating physiological behaviors, including memory formation and sleep. However, the detailed mechanisms by which neuropeptides regulate these physiological behaviors remains unclear. Herein, we report that neuropeptide diuretic hormone 31 (DH31) positively regulates memory formation and sleep in Drosophila melanogaster. The expression of DH31 in the dorsal and ventral fan-shaped body (dFB and vFB) neurons of the central complex and ventral lateral clock neurons (LNvs) in the brain was responsive to sleep regulation. In addition, the expression of membrane-tethered DH31 in dFB neurons rescued sleep defects in Dh31 mutants, suggesting that DH31 secreted from dFB, vFB, and LNvs acts on the DH31 receptor in the dFB to regulate sleep partly in an autoregulatory feedback loop. Moreover, the expression of DH31 in octopaminergic neurons, but not in the dFB neurons, is involved in forming intermediate-term memory. Our results suggest that DH31 regulates memory formation and sleep through distinct neural pathways. •Sleep and memory formation impaired in DH31 mutant or DH31 knocked down flies.•Knock down of DH31 in fan-shaped body neurons significantly reduce sleep.•DH31 in octopaminergic neurons regulates memory formation.•DH31 mediates sleep and memory via distinct neural pathways.
ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2023.02.003