Diagnostic Accuracy of Liquid Biopsy for Oral Potentially Malignant Disorders and Head and Neck Cancer: an Overview of Systematic Reviews

• Published in: Current oncology reports 2023-04, Vol.25 (4), p.279-292
• Main Authors: Araújo, Anna Luíza Damaceno, Santos-Silva, Alan Roger, Kowalski, Luiz Paulo
• Format: Article
• Language: English
• Subjects: Biomarkers; Biopsy; Diagnosis; Early Detection of Cancer; Head & neck cancer; Head and Neck Cancers (Ey Hanna; Humans; Liquid Biopsy; Medical diagnosis; Medicine; Medicine & Public Health; MicroRNAs; Mouth Neoplasms - diagnosis; Mouth Neoplasms - pathology; Oncology; Oral cancer; Otolaryngology; Saliva; Section Editor; Squamous cell carcinoma; Systematic review; Systematic Reviews as Topic; Topical Collection on Head and Neck Cancers
• ISSN: 1523-3790; 1534-6269
• DOI: 10.1007/s11912-023-01365-w

Purpose of Review The aim of this overview is to appraise the evidence on salivary biomarkers for H&N cancer diagnosis. The acronym PICOS was used to develop the eligibility criteria and the focused review question: are liquid biopsies (saliva biomarkers) reliable for cancer detection in H&N cancer patients? Electronic database search encompassed PubMed, EMBASE, Scopus, Cochrane Library, Web of Science, and LILACS. Risk of Bias (RoB) was assessed through AMSTAR 2. Recent Findings A total of 20 SRs were included. Only seven SRs were able to reach more solid conclusions around the retrieved findings by calculating the pooled sensitivity, specificity, and the overall area under the curve (AUC). Summary Despite the limitations, significant RoB, and lack of test metrics in primary studies, all SRs recognize and encourage the potential role of saliva in the early diagnosis of oral cancer.