Weight loss and abnormal lung inflammation in mice chronically exposed to secondary organic aerosols

Secondary organic aerosols (SOAs) have emerged recently as a major component of fine particulate matter. Cell culture studies revealed a role for SOAs in cell oxidative stress, toxicity and inflammation and only a few studies investigated short-term SOA exposure in animal models. Here, mice were chr...

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Bibliographic Details
Published in:Environmental science--processes & impacts 2023-03, Vol.25 (3), p.382-388
Main Authors: Déméautis, Tanguy, Bouyssi, Alexandra, Geloen, Alain, George, Christian, Menotti, Jean, Glehen, Olivier, Devouassoux, Gilles, Bentaher, Abderrazzak
Format: Article
Language:English
Subjects:
Aerosols
Animal models
Animals
Antibodies
Antibody microarrays
Biocompatibility
Catalysis
Cell culture
Chemical Sciences
Chronic exposure
Chronic obstructive pulmonary disease
Cigarette smoke
Environment and Society
Environmental Sciences
Exposure
Female
Humans
In vivo methods and tests
Inflammation
Lung diseases
Lungs
Mice
Naphthalene
Obstructive lung disease
Oxidative Stress
Particulate matter
Particulate Matter - toxicity
Pneumonia - chemically induced
Respiratory Aerosols and Droplets
Sex differences
Toxicity
Weight Loss
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Summary:Secondary organic aerosols (SOAs) have emerged recently as a major component of fine particulate matter. Cell culture studies revealed a role for SOAs in cell oxidative stress, toxicity and inflammation and only a few studies investigated short-term SOA exposure in animal models. Here, mice were chronically exposed to naphthalene-derived SOAs for one and two months. Weight monitoring indicated a marked mass loss, especially in females, following chronic exposure to SOAs. Significantly, a cytokine antibody microarray approach revealed SOA-induced abnormal lung inflammation similar to that seen in cigarette smoke-induced chronic obstructive pulmonary disease (COPD). This in vivo study testifies to the pathogenic role of sub-chronic SOA exposure on human health. Chronic exposure to SOAs induces sex-dependent weight loss and abnormal inflammation.
ISSN:2050-7887
2050-7895
DOI:10.1039/d2em00423b