Pharmacological effects of Raphanus caudatus in inflammation and hematopoitic system: an in vitro and in vivo investigation

The pods of Radish are known as Raphanus caudatus that belongs to the family Brassicaceae. They are commonly known as Mungra or Sungra in Pakistan, while the common English name for this species is Rat-tailed radish. This variety of radish is unique and less tested for pharmacological as well as tox...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2022-11, Vol.35 (6), p.1495-1501
Main Authors: Younus, Ishrat, Siddiq, Afshan, Baig, Sadia Ghousia, Mujeeb, Nimra
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Blood cells
Care and treatment
Caudate Nucleus
Chemical properties
Daikon
Edema - chemically induced
Edema - drug therapy
Health aspects
Inflammation
Inflammation - chemically induced
Inflammation - drug therapy
Phytochemicals
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Radishes
Raphanus
Rats
Rats, Wistar
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Summary:The pods of Radish are known as Raphanus caudatus that belongs to the family Brassicaceae. They are commonly known as Mungra or Sungra in Pakistan, while the common English name for this species is Rat-tailed radish. This variety of radish is unique and less tested for pharmacological as well as toxicological potential. In the current research, the ethanol extract of pods was assessed for anti-inflammatory potential in vitro and in vivo. Furthermore the effect of plant on hematological parameters was also investigated. For in vitro study, luminol-enhanced chemiluminescence method was used while in vivo study was carried out via Acetic acid- induced Paw Edema Test in wistar rats. The extract of Raphanus caudatus indicated significant anti-inflammatory effects regarding in vitro assay. Administered tested doses (250mg, 500mg and 1000mg/kg) of plant extract showed significant reduction in rat's paw but highest in vivo anti-inflammatory effect was observed at the dose of 1000mg/kg. Moreover, in the case of hematological study, noticeable elevation of white blood cell count was observed at 500 and 1000 mg/kg. However the number of platelets was reduced in dose dependent manner.
ISSN:1011-601X
DOI:10.36721/PJPS.2022.35.6.REG.1495-1501.1