Pharmacological effects of Raphanus caudatus in inflammation and hematopoitic system: an in vitro and in vivo investigation

• Published in: Pakistan journal of pharmaceutical sciences 2022-11, Vol.35 (6), p.1495-1501
• Main Authors: Younus, Ishrat, Siddiq, Afshan, Baig, Sadia Ghousia, Mujeeb, Nimra
• Format: Article
• Language: English
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Blood cells; Care and treatment; Caudate Nucleus; Chemical properties; Daikon; Edema - chemically induced; Edema - drug therapy; Health aspects; Inflammation; Inflammation - chemically induced; Inflammation - drug therapy; Phytochemicals; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Radishes; Raphanus; Rats; Rats, Wistar
• ISSN: 1011-601X
• DOI: 10.36721/PJPS.2022.35.6.REG.1495-1501.1

The pods of Radish are known as Raphanus caudatus that belongs to the family Brassicaceae. They are commonly known as Mungra or Sungra in Pakistan, while the common English name for this species is Rat-tailed radish. This variety of radish is unique and less tested for pharmacological as well as toxicological potential. In the current research, the ethanol extract of pods was assessed for anti-inflammatory potential in vitro and in vivo. Furthermore the effect of plant on hematological parameters was also investigated. For in vitro study, luminol-enhanced chemiluminescence method was used while in vivo study was carried out via Acetic acid- induced Paw Edema Test in wistar rats. The extract of Raphanus caudatus indicated significant anti-inflammatory effects regarding in vitro assay. Administered tested doses (250mg, 500mg and 1000mg/kg) of plant extract showed significant reduction in rat's paw but highest in vivo anti-inflammatory effect was observed at the dose of 1000mg/kg. Moreover, in the case of hematological study, noticeable elevation of white blood cell count was observed at 500 and 1000 mg/kg. However the number of platelets was reduced in dose dependent manner.