Immunosuppressive Bibenzyl‐phenylpropane Hybrids from Dendrobium devonianum

Two new bibenzyl‐phenylpropane hybrids, dendrophenols A and B (1 and 2), along with nine known bibenzyls, were isolated from the aerial part of Dendrobium devonianum Paxt. Their structures were determined by extensive spectroscopic methods and methylation. Bioassays revealed that compounds 1–9 were...

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Bibliographic Details
Published in:Chemistry & biodiversity 2023-03, Vol.20 (3), p.e202201185-n/a
Main Authors: Zhan, Rui, Zhang, Xin‐Yue, Li, Zhi‐Yuan, Liu, Bo, Chen, Ye‐Gao
Format: Article
Language:English
Subjects:
bibenzyl-phenylpropane hybrids
Bibenzyls - chemistry
Bibenzyls - pharmacology
Bioassays
Dendrobium
Dendrobium - chemistry
Dendrobium devonianum
Free Radical Scavengers - chemistry
Hybrids
immunosuppressive
Immunosuppressive agents
Lymphocytes
Lymphocytes T
Magnetic Resonance Spectroscopy
Methylation
Molecular Structure
Selectivity
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Summary:Two new bibenzyl‐phenylpropane hybrids, dendrophenols A and B (1 and 2), along with nine known bibenzyls, were isolated from the aerial part of Dendrobium devonianum Paxt. Their structures were determined by extensive spectroscopic methods and methylation. Bioassays revealed that compounds 1–9 were specifically immunosuppressive to T lymphocytes with IC50 values ranging from 0.41 to 9.4 μM, of which compounds 1 (IC50=1.62 μM) and 2 (IC50=0.41 μM) were promising immunosuppressive agents for T lymphocytes with the selectivity indices of 19.9 and 79.5, respectively. Dendrophenols A and B (1 and 2) were new bibenzyl‐phenylpropane hybrids isolated from the aerial part of Dendrobium devonianum Paxt. Compound 2 (IC50=0.41 μM) was a promising immunosuppressive agent for T lymphocytes.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202201185