Microglia C-lectin/selectin' neurons to eat

β-glucosylceramide (β-GlcCer) accumulates in Gaucher disease, but how β-GlcCer, a Mincle ligand, causes characteristic neuroinflammation and neuronopathy is poorly understood. In this issue of Immunity, Shimizu et al. reveal that Mincle-dependent activation of microglia led to phagocytosis of neuron...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2023-02, Vol.56 (2), p.227-229
Main Authors: Jiang, Yike, Shinohara, Mari L.
Format: Article
Language:English
Subjects:
Lectins
Microglia
Neurons
Phagocytosis
Selectins
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Summary:β-glucosylceramide (β-GlcCer) accumulates in Gaucher disease, but how β-GlcCer, a Mincle ligand, causes characteristic neuroinflammation and neuronopathy is poorly understood. In this issue of Immunity, Shimizu et al. reveal that Mincle-dependent activation of microglia led to phagocytosis of neurons and neurologic symptoms. β-glucosylceramide (β-GlcCer) accumulates in Gaucher disease, but how β-GlcCer, a Mincle ligand, causes characteristic neuroinflammation and neuronopathy is poorly understood. In this issue of Immunity, Shimizu et al. reveal that Mincle-dependent activation of microglia led to phagocytosis of neurons and neurologic symptoms.
ISSN:1074-7613
1097-4180
1097-4180
DOI:10.1016/j.immuni.2023.01.020