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GluCEST Imaging and Structural Alterations of the Bilateral Hippocampus in First-Episode and Early-Onset Major Depression Disorder
Glutamate dysregulation is one of the key pathogenic mechanisms of major depressive disorder (MDD), and glutamate chemical exchange saturation transfer (GluCEST) has been used for glutamate measurement in some brain diseases but rarely in depression. To investigate the GluCEST changes in hippocampus...
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| Published in: | Journal of magnetic resonance imaging 2023-11, Vol.58 (5), p.1431-1440 |
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| cites | cdi_FETCH-LOGICAL-c351t-7e199021636eb7a0c23875ba3190a0fdacc7bc46baeceb64968872906e6478f93 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Zeng, Zhen Dong, Yingying Zou, Linxuan Xu, Donghao Luo, Xunrong Chu, Tongpeng Wang, Jing Ren, Qingfa Liu, Quanyuan Li, Xianglin |
| description | Glutamate dysregulation is one of the key pathogenic mechanisms of major depressive disorder (MDD), and glutamate chemical exchange saturation transfer (GluCEST) has been used for glutamate measurement in some brain diseases but rarely in depression.
To investigate the GluCEST changes in hippocampus in MDD and the relationship between glutamate and hippocampal subregional volumes.
Cross-sectional.
Thirty-two MDD patients (34% males; 22.03 ± 7.21 years) and 47 healthy controls (HCs) (43% males; 22.00 ± 3.28 years).
3.0 T; magnetization prepared rapid gradient echo (MPRAGE) for three-dimensional T1-weighted images, two-dimensional turbo spin echo GluCEST, and multivoxel chemical shift imaging (CSI) for proton magnetic resonance spectroscopy (
H MRS).
GluCEST data were quantified by magnetization transfer ratio asymmetry (MTR
) analysis and assessed by the relative concentration of
H MRS-measured glutamate. FreeSurfer was used for hippocampus segmentation.
The independent sample t test, Mann-Whitney U test, Spearman's correlation, and partial correlation analysis were used. P |
| doi_str_mv | 10.1002/jmri.28651 |
| format | article |
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To investigate the GluCEST changes in hippocampus in MDD and the relationship between glutamate and hippocampal subregional volumes.
Cross-sectional.
Thirty-two MDD patients (34% males; 22.03 ± 7.21 years) and 47 healthy controls (HCs) (43% males; 22.00 ± 3.28 years).
3.0 T; magnetization prepared rapid gradient echo (MPRAGE) for three-dimensional T1-weighted images, two-dimensional turbo spin echo GluCEST, and multivoxel chemical shift imaging (CSI) for proton magnetic resonance spectroscopy (
H MRS).
GluCEST data were quantified by magnetization transfer ratio asymmetry (MTR
) analysis and assessed by the relative concentration of
H MRS-measured glutamate. FreeSurfer was used for hippocampus segmentation.
The independent sample t test, Mann-Whitney U test, Spearman's correlation, and partial correlation analysis were used. P < 0.05 was considered statistically significant.
In the left hippocampus, GluCEST values were significantly decreased in MDD (2.00 ± 1.08 [MDD] vs. 2.62 ± 1.41 [HCs]) and showed a significantly positive correlation with Glx/Cr (r = 0.37). GluCEST values were significantly positively correlated with the volumes of CA1 (r = 0.40), subiculum (r = 0.40) in the left hippocampus and CA1 (r = 0.51), molecular_layer_HP (r = 0.50), GC-ML-DG (r = 0.42), CA3 (r = 0.44), CA4 (r = 0.44), hippocampus-amygdala-transition-area (r = 0.46), and the whole hippocampus (r = 0.47) in the right hippocampus. Hamilton Depression Rating Scale scores showed significantly negative correlations with the volumes of the left presubiculum (r = -0.40), left parasubiculum (r = -0.47), and right presubiculum (r = -0.41).
GluCEST can be used to measure glutamate changes and help to understand the mechanism of hippocampal volume loss in MDD. Hippocampal volume changes are associated with disease severity.
2 TECHNICAL EFFICACY: Stage 1.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.28651</identifier><identifier>PMID: 36808678</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Amygdala ; Chemical equilibrium ; Correlation analysis ; Field strength ; Hippocampus ; Image segmentation ; Magnetic resonance imaging ; Magnetic resonance spectroscopy ; Magnetization ; Males ; Medical imaging ; Mental depression ; Mental disorders ; Neuroimaging ; Presubiculum ; Proton magnetic resonance ; Statistical analysis ; Statistical tests ; Subiculum</subject><ispartof>Journal of magnetic resonance imaging, 2023-11, Vol.58 (5), p.1431-1440</ispartof><rights>2023 International Society for Magnetic Resonance in Medicine.</rights><rights>2023 International Society for Magnetic Resonance in Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-7e199021636eb7a0c23875ba3190a0fdacc7bc46baeceb64968872906e6478f93</citedby><cites>FETCH-LOGICAL-c351t-7e199021636eb7a0c23875ba3190a0fdacc7bc46baeceb64968872906e6478f93</cites><orcidid>0000-0002-4406-6621 ; 0000-0003-4469-3390 ; 0000-0002-6854-4149</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36808678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Zhen</creatorcontrib><creatorcontrib>Dong, Yingying</creatorcontrib><creatorcontrib>Zou, Linxuan</creatorcontrib><creatorcontrib>Xu, Donghao</creatorcontrib><creatorcontrib>Luo, Xunrong</creatorcontrib><creatorcontrib>Chu, Tongpeng</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Ren, Qingfa</creatorcontrib><creatorcontrib>Liu, Quanyuan</creatorcontrib><creatorcontrib>Li, Xianglin</creatorcontrib><title>GluCEST Imaging and Structural Alterations of the Bilateral Hippocampus in First-Episode and Early-Onset Major Depression Disorder</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Glutamate dysregulation is one of the key pathogenic mechanisms of major depressive disorder (MDD), and glutamate chemical exchange saturation transfer (GluCEST) has been used for glutamate measurement in some brain diseases but rarely in depression.
To investigate the GluCEST changes in hippocampus in MDD and the relationship between glutamate and hippocampal subregional volumes.
Cross-sectional.
Thirty-two MDD patients (34% males; 22.03 ± 7.21 years) and 47 healthy controls (HCs) (43% males; 22.00 ± 3.28 years).
3.0 T; magnetization prepared rapid gradient echo (MPRAGE) for three-dimensional T1-weighted images, two-dimensional turbo spin echo GluCEST, and multivoxel chemical shift imaging (CSI) for proton magnetic resonance spectroscopy (
H MRS).
GluCEST data were quantified by magnetization transfer ratio asymmetry (MTR
) analysis and assessed by the relative concentration of
H MRS-measured glutamate. FreeSurfer was used for hippocampus segmentation.
The independent sample t test, Mann-Whitney U test, Spearman's correlation, and partial correlation analysis were used. P < 0.05 was considered statistically significant.
In the left hippocampus, GluCEST values were significantly decreased in MDD (2.00 ± 1.08 [MDD] vs. 2.62 ± 1.41 [HCs]) and showed a significantly positive correlation with Glx/Cr (r = 0.37). GluCEST values were significantly positively correlated with the volumes of CA1 (r = 0.40), subiculum (r = 0.40) in the left hippocampus and CA1 (r = 0.51), molecular_layer_HP (r = 0.50), GC-ML-DG (r = 0.42), CA3 (r = 0.44), CA4 (r = 0.44), hippocampus-amygdala-transition-area (r = 0.46), and the whole hippocampus (r = 0.47) in the right hippocampus. Hamilton Depression Rating Scale scores showed significantly negative correlations with the volumes of the left presubiculum (r = -0.40), left parasubiculum (r = -0.47), and right presubiculum (r = -0.41).
GluCEST can be used to measure glutamate changes and help to understand the mechanism of hippocampal volume loss in MDD. Hippocampal volume changes are associated with disease severity.
2 TECHNICAL EFFICACY: Stage 1.</description><subject>Amygdala</subject><subject>Chemical equilibrium</subject><subject>Correlation analysis</subject><subject>Field strength</subject><subject>Hippocampus</subject><subject>Image segmentation</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic resonance spectroscopy</subject><subject>Magnetization</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Neuroimaging</subject><subject>Presubiculum</subject><subject>Proton magnetic resonance</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Subiculum</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkctq3DAUQEVoyavZ9AOKoJsS8FQPW49lMpk8ICWLTNZGlq9TDbLlSvIi2355PJNJFlndy-VwuHAQ-k7JghLCfm_66BZMiYoeoGNaMVawSokv804qXlBF5BE6SWlDCNG6rA7REReKKCHVMfp_46fl6nGN73rz7IZnbIYWP-Y42TxF4_GFzxBNdmFIOHQ4_wV86bzZHj2-deMYrOnHKWE34GsXUy5Wo0uhhZ1oZaJ_KR6GBBn_MZsQ8RWMEVKaffhq5mIL8Rv62hmf4Gw_T9HT9Wq9vC3uH27ulhf3heUVzYUEqjVhVHABjTTEMq5k1RhONTGka421srGlaAxYaESphVKSaSJAlFJ1mp-iX2_eMYZ_E6Rc9y5Z8N4MEKZUMymVlqws-Yz-_IRuwhSH-buaKVkKxTVXM3X-RtkYUorQ1WN0vYkvNSX1tky9LVPvyszwj71yanpoP9D3FPwVfaOJ7g</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Zeng, Zhen</creator><creator>Dong, Yingying</creator><creator>Zou, Linxuan</creator><creator>Xu, Donghao</creator><creator>Luo, Xunrong</creator><creator>Chu, Tongpeng</creator><creator>Wang, Jing</creator><creator>Ren, Qingfa</creator><creator>Liu, Quanyuan</creator><creator>Li, Xianglin</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4406-6621</orcidid><orcidid>https://orcid.org/0000-0003-4469-3390</orcidid><orcidid>https://orcid.org/0000-0002-6854-4149</orcidid></search><sort><creationdate>20231101</creationdate><title>GluCEST Imaging and Structural Alterations of the Bilateral Hippocampus in First-Episode and Early-Onset Major Depression Disorder</title><author>Zeng, Zhen ; Dong, Yingying ; Zou, Linxuan ; Xu, Donghao ; Luo, Xunrong ; Chu, Tongpeng ; Wang, Jing ; Ren, Qingfa ; Liu, Quanyuan ; Li, Xianglin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-7e199021636eb7a0c23875ba3190a0fdacc7bc46baeceb64968872906e6478f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amygdala</topic><topic>Chemical equilibrium</topic><topic>Correlation analysis</topic><topic>Field strength</topic><topic>Hippocampus</topic><topic>Image segmentation</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic resonance spectroscopy</topic><topic>Magnetization</topic><topic>Males</topic><topic>Medical imaging</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Neuroimaging</topic><topic>Presubiculum</topic><topic>Proton magnetic resonance</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>Subiculum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Zhen</creatorcontrib><creatorcontrib>Dong, Yingying</creatorcontrib><creatorcontrib>Zou, Linxuan</creatorcontrib><creatorcontrib>Xu, Donghao</creatorcontrib><creatorcontrib>Luo, Xunrong</creatorcontrib><creatorcontrib>Chu, Tongpeng</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Ren, Qingfa</creatorcontrib><creatorcontrib>Liu, Quanyuan</creatorcontrib><creatorcontrib>Li, Xianglin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Zhen</au><au>Dong, Yingying</au><au>Zou, Linxuan</au><au>Xu, Donghao</au><au>Luo, Xunrong</au><au>Chu, Tongpeng</au><au>Wang, Jing</au><au>Ren, Qingfa</au><au>Liu, Quanyuan</au><au>Li, Xianglin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GluCEST Imaging and Structural Alterations of the Bilateral Hippocampus in First-Episode and Early-Onset Major Depression Disorder</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>58</volume><issue>5</issue><spage>1431</spage><epage>1440</epage><pages>1431-1440</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Glutamate dysregulation is one of the key pathogenic mechanisms of major depressive disorder (MDD), and glutamate chemical exchange saturation transfer (GluCEST) has been used for glutamate measurement in some brain diseases but rarely in depression.
To investigate the GluCEST changes in hippocampus in MDD and the relationship between glutamate and hippocampal subregional volumes.
Cross-sectional.
Thirty-two MDD patients (34% males; 22.03 ± 7.21 years) and 47 healthy controls (HCs) (43% males; 22.00 ± 3.28 years).
3.0 T; magnetization prepared rapid gradient echo (MPRAGE) for three-dimensional T1-weighted images, two-dimensional turbo spin echo GluCEST, and multivoxel chemical shift imaging (CSI) for proton magnetic resonance spectroscopy (
H MRS).
GluCEST data were quantified by magnetization transfer ratio asymmetry (MTR
) analysis and assessed by the relative concentration of
H MRS-measured glutamate. FreeSurfer was used for hippocampus segmentation.
The independent sample t test, Mann-Whitney U test, Spearman's correlation, and partial correlation analysis were used. P < 0.05 was considered statistically significant.
In the left hippocampus, GluCEST values were significantly decreased in MDD (2.00 ± 1.08 [MDD] vs. 2.62 ± 1.41 [HCs]) and showed a significantly positive correlation with Glx/Cr (r = 0.37). GluCEST values were significantly positively correlated with the volumes of CA1 (r = 0.40), subiculum (r = 0.40) in the left hippocampus and CA1 (r = 0.51), molecular_layer_HP (r = 0.50), GC-ML-DG (r = 0.42), CA3 (r = 0.44), CA4 (r = 0.44), hippocampus-amygdala-transition-area (r = 0.46), and the whole hippocampus (r = 0.47) in the right hippocampus. Hamilton Depression Rating Scale scores showed significantly negative correlations with the volumes of the left presubiculum (r = -0.40), left parasubiculum (r = -0.47), and right presubiculum (r = -0.41).
GluCEST can be used to measure glutamate changes and help to understand the mechanism of hippocampal volume loss in MDD. Hippocampal volume changes are associated with disease severity.
2 TECHNICAL EFFICACY: Stage 1.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36808678</pmid><doi>10.1002/jmri.28651</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4406-6621</orcidid><orcidid>https://orcid.org/0000-0003-4469-3390</orcidid><orcidid>https://orcid.org/0000-0002-6854-4149</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of magnetic resonance imaging, 2023-11, Vol.58 (5), p.1431-1440 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Amygdala Chemical equilibrium Correlation analysis Field strength Hippocampus Image segmentation Magnetic resonance imaging Magnetic resonance spectroscopy Magnetization Males Medical imaging Mental depression Mental disorders Neuroimaging Presubiculum Proton magnetic resonance Statistical analysis Statistical tests Subiculum |
| title | GluCEST Imaging and Structural Alterations of the Bilateral Hippocampus in First-Episode and Early-Onset Major Depression Disorder |
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