Effect of soluble corn fibre and calcium supplementation on bone mineral content and bone mineral density in preadolescent Malaysian children—a double-blind randomised controlled trial (PREBONE-Kids Study)

Summary Soluble corn fibre (SCF) with calcium did not improve bone indices after 1 year in preadolescent children. Introduction SCF has been reported to improve calcium absorption. We investigated the long-term effect of SCF and calcium on bone indices of healthy preadolescent children aged 9–11 yea...

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Published in:Osteoporosis international 2023-04, Vol.34 (4), p.783-792
Main Authors: Arasu, Kanimolli, Chang, Chung Yuan, Wong, Soon Yee, Ong, Shu Hwa, Yang, Wai Yew, Chong, Megan Hueh Zan, Mavinkurve, Meenal, Khoo, Erwin Jiayuan, Chinna, Karuthan, Weaver, Connie M., Chee, Winnie Siew Swee
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Bone Density
Bone mineral content
Bone mineral density
Calcium - therapeutic use
Calcium absorption
Calcium Gluconate - pharmacology
Calcium, Dietary - pharmacology
Child
Children
Clinical trials
Dietary Supplements
Double-Blind Method
Double-blind studies
Dual energy X-ray absorptiometry
Endocrinology
Humans
Lactic acid
Medicine
Medicine & Public Health
Original Article
Orthopedics
Osteoporosis
Placebos
Population studies
Prebiotics
Rheumatology
Supplements
Zea mays
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Summary:Summary Soluble corn fibre (SCF) with calcium did not improve bone indices after 1 year in preadolescent children. Introduction SCF has been reported to improve calcium absorption. We investigated the long-term effect of SCF and calcium on bone indices of healthy preadolescent children aged 9–11 years old. Methods In a double-blind, randomised, parallel arm study, 243 participants were randomised into four groups: placebo, 12-g SCF, 600-mg calcium lactate gluconate (Ca) and 12-g SCF + 600-mg calcium lactate gluconate (SCF + Ca). Total body bone mineral content (TBBMC) and total body bone mineral density (TBBMD) were measured using dual-energy X-ray absorptiometry at baseline, 6 and 12 months. Results At 6 months, SCF + Ca had a significant increase in TBBMC from baseline (27.14 ± 6.10 g, p  = 0.001). At 12 months, there was a significant increase in TBBMC from baseline in the SCF + Ca (40.28 ± 9.03 g, p  = 0.001) and SCF groups (27.34 ± 7.93 g, p  = 0.037). At 6 months, the change in TBBMD in the SCF + Ca (0.019 ± 0.003 g/cm 2 ) and Ca (0.014 ± 0.003 g/cm 2 ) groups was significantly different ( p  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-023-06702-0