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Trends in Modifiable Risk Factors Amongst First Presentation ST Elevation Myocardial Infarction Patients in a Large Longitudinal Registry
Recent studies suggest that the risk factor profile of patients presenting with ST elevation myocardial infarction (STEMI) is changing. The aim is to determine if there has been a shift of cardiovascular risk factors to cardiometabolic causes in the first presentation STEMI population. We analysed d...
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| Published in: | Heart, lung & circulation lung & circulation, 2023-04, Vol.32 (4), p.480-486 |
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| container_end_page | 486 |
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| container_title | Heart, lung & circulation |
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| creator | Kazi, Samia N. Von Huben, Amy Marschner, Simone Chong, James J.H. Denniss, Alan Robert Ong, Andrew T.L. Chow, Clara K. |
| description | Recent studies suggest that the risk factor profile of patients presenting with ST elevation myocardial infarction (STEMI) is changing.
The aim is to determine if there has been a shift of cardiovascular risk factors to cardiometabolic causes in the first presentation STEMI population.
We analysed data from a STEMI registry from a large tertiary referral percutaneous coronary intervention centre to determine the prevalence and trends of the modifiable risk factors of hypertension, diabetes, smoking and hypercholesterolaemia.
Consecutive first presentation STEMI patients between January 2006 to December 2018.
Among the 2,366 patients included (mean age 59, SD 12.66, 80% male) the common risk factors were hypertension (47%), hypercholesterolaemia (47%) current smoking (42%) and diabetes (27%). Over the 13 years, patients with diabetes (20% to 26%, OR 1.09 per year, CI 1.06–1.11, p |
| doi_str_mv | 10.1016/j.hlc.2022.12.012 |
| format | article |
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The aim is to determine if there has been a shift of cardiovascular risk factors to cardiometabolic causes in the first presentation STEMI population.
We analysed data from a STEMI registry from a large tertiary referral percutaneous coronary intervention centre to determine the prevalence and trends of the modifiable risk factors of hypertension, diabetes, smoking and hypercholesterolaemia.
Consecutive first presentation STEMI patients between January 2006 to December 2018.
Among the 2,366 patients included (mean age 59, SD 12.66, 80% male) the common risk factors were hypertension (47%), hypercholesterolaemia (47%) current smoking (42%) and diabetes (27%). Over the 13 years, patients with diabetes (20% to 26%, OR 1.09 per year, CI 1.06–1.11, p<0.001) and patients with no modifiable risk factors increased (9% to 17%, OR 1.08, CI 1.04–1.11, p<0.001). Concurrently there was a fall in prevalence of hypercholesterolaemia, (47% to 37%, OR 0.94 per year, CI 0.92–0.96, p<0.001) and smoking (44% to 41%, OR 0.94, CI 0.92–0.96, p<0.001) but no significant change in rates of hypertension (53% to 49%, OR 0.99, CI 0.97–1.01, p=0.25).
The risk factor profile of first presentation STEMI has changed over time with a reduction in smoking and a concurrent rise in patients with no traditional risk factors. This suggests the mechanism of STEMI may be changing and further investigation of potential causal factors is warranted for the prevention and management of cardiovascular disease.</description><identifier>ISSN: 1443-9506</identifier><identifier>EISSN: 1444-2892</identifier><identifier>DOI: 10.1016/j.hlc.2022.12.012</identifier><identifier>PMID: 36801127</identifier><language>eng</language><publisher>Australia: Elsevier B.V</publisher><subject>Cardiometabolic risk factors ; Cardiovascular diseases ; Diabetes Mellitus - epidemiology ; Female ; Heart disease risk factors ; Humans ; Hypercholesterolemia - complications ; Hypercholesterolemia - epidemiology ; Hypertension - complications ; Hypertension - epidemiology ; Male ; Middle Aged ; Myocardial infarction ; Percutaneous Coronary Intervention ; Registries ; Risk Factors ; ST elevation myocardial infarction ; ST Elevation Myocardial Infarction - diagnosis ; ST Elevation Myocardial Infarction - epidemiology ; Treatment Outcome</subject><ispartof>Heart, lung & circulation, 2023-04, Vol.32 (4), p.480-486</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-36b17ef156109dffa899c92a89edf9ed0acdcae9176d36779b5f6af51f57db1b3</citedby><cites>FETCH-LOGICAL-c353t-36b17ef156109dffa899c92a89edf9ed0acdcae9176d36779b5f6af51f57db1b3</cites><orcidid>0000-0001-6976-5835 ; 0000-0003-4693-0038 ; 0000-0002-5484-9144</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36801127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kazi, Samia N.</creatorcontrib><creatorcontrib>Von Huben, Amy</creatorcontrib><creatorcontrib>Marschner, Simone</creatorcontrib><creatorcontrib>Chong, James J.H.</creatorcontrib><creatorcontrib>Denniss, Alan Robert</creatorcontrib><creatorcontrib>Ong, Andrew T.L.</creatorcontrib><creatorcontrib>Chow, Clara K.</creatorcontrib><title>Trends in Modifiable Risk Factors Amongst First Presentation ST Elevation Myocardial Infarction Patients in a Large Longitudinal Registry</title><title>Heart, lung & circulation</title><addtitle>Heart Lung Circ</addtitle><description>Recent studies suggest that the risk factor profile of patients presenting with ST elevation myocardial infarction (STEMI) is changing.
The aim is to determine if there has been a shift of cardiovascular risk factors to cardiometabolic causes in the first presentation STEMI population.
We analysed data from a STEMI registry from a large tertiary referral percutaneous coronary intervention centre to determine the prevalence and trends of the modifiable risk factors of hypertension, diabetes, smoking and hypercholesterolaemia.
Consecutive first presentation STEMI patients between January 2006 to December 2018.
Among the 2,366 patients included (mean age 59, SD 12.66, 80% male) the common risk factors were hypertension (47%), hypercholesterolaemia (47%) current smoking (42%) and diabetes (27%). Over the 13 years, patients with diabetes (20% to 26%, OR 1.09 per year, CI 1.06–1.11, p<0.001) and patients with no modifiable risk factors increased (9% to 17%, OR 1.08, CI 1.04–1.11, p<0.001). Concurrently there was a fall in prevalence of hypercholesterolaemia, (47% to 37%, OR 0.94 per year, CI 0.92–0.96, p<0.001) and smoking (44% to 41%, OR 0.94, CI 0.92–0.96, p<0.001) but no significant change in rates of hypertension (53% to 49%, OR 0.99, CI 0.97–1.01, p=0.25).
The risk factor profile of first presentation STEMI has changed over time with a reduction in smoking and a concurrent rise in patients with no traditional risk factors. This suggests the mechanism of STEMI may be changing and further investigation of potential causal factors is warranted for the prevention and management of cardiovascular disease.</description><subject>Cardiometabolic risk factors</subject><subject>Cardiovascular diseases</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Female</subject><subject>Heart disease risk factors</subject><subject>Humans</subject><subject>Hypercholesterolemia - complications</subject><subject>Hypercholesterolemia - epidemiology</subject><subject>Hypertension - complications</subject><subject>Hypertension - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial infarction</subject><subject>Percutaneous Coronary Intervention</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>ST elevation myocardial infarction</subject><subject>ST Elevation Myocardial Infarction - diagnosis</subject><subject>ST Elevation Myocardial Infarction - epidemiology</subject><subject>Treatment Outcome</subject><issn>1443-9506</issn><issn>1444-2892</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc9uGyEQxlHVqPnXB-il4tjLbhjWuyzqKYriNJKjRolzRiwMLu56SQFH8iP0rUvstMcemGHgNx9iPkI-AauBQXexrn-MpuaM8xp4zYC_Iycwm80q3kv-fr9vKtmy7picprRmDMSskR_IcdP1DICLE_J7GXGyifqJ3gXrndfDiPTBp590rk0OMdHLTZhWKdO5jyXeR0w4ZZ19mOjjkl6P-HIo7nbB6Gi9Hunt5HQ0-9P7cln4_QuaLnRcIV0UQZ-31k-FfcCVTznuzsmR02PCj2_5jDzNr5dX36rF95vbq8tFZZq2yVXTDSDQQdsBk9Y53UtpJC8JrSuLaWONRgmis00nhBxa12nXgmuFHWBozsiXg-5zDL-2mLLa-GRwHPWEYZsUF6KXomdtW1A4oCaGlCI69Rz9RsedAqZeHVBrVRxQrw4o4Ko4UHo-v8lvhw3afx1_R16ArwcAyydfPEaVTJmQQesjmqxs8P-R_wOeyZlA</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Kazi, Samia N.</creator><creator>Von Huben, Amy</creator><creator>Marschner, Simone</creator><creator>Chong, James J.H.</creator><creator>Denniss, Alan Robert</creator><creator>Ong, Andrew T.L.</creator><creator>Chow, Clara K.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6976-5835</orcidid><orcidid>https://orcid.org/0000-0003-4693-0038</orcidid><orcidid>https://orcid.org/0000-0002-5484-9144</orcidid></search><sort><creationdate>202304</creationdate><title>Trends in Modifiable Risk Factors Amongst First Presentation ST Elevation Myocardial Infarction Patients in a Large Longitudinal Registry</title><author>Kazi, Samia N. ; Von Huben, Amy ; Marschner, Simone ; Chong, James J.H. ; Denniss, Alan Robert ; Ong, Andrew T.L. ; Chow, Clara K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-36b17ef156109dffa899c92a89edf9ed0acdcae9176d36779b5f6af51f57db1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiometabolic risk factors</topic><topic>Cardiovascular diseases</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Female</topic><topic>Heart disease risk factors</topic><topic>Humans</topic><topic>Hypercholesterolemia - complications</topic><topic>Hypercholesterolemia - epidemiology</topic><topic>Hypertension - complications</topic><topic>Hypertension - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial infarction</topic><topic>Percutaneous Coronary Intervention</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>ST elevation myocardial infarction</topic><topic>ST Elevation Myocardial Infarction - diagnosis</topic><topic>ST Elevation Myocardial Infarction - epidemiology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kazi, Samia N.</creatorcontrib><creatorcontrib>Von Huben, Amy</creatorcontrib><creatorcontrib>Marschner, Simone</creatorcontrib><creatorcontrib>Chong, James J.H.</creatorcontrib><creatorcontrib>Denniss, Alan Robert</creatorcontrib><creatorcontrib>Ong, Andrew T.L.</creatorcontrib><creatorcontrib>Chow, Clara K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Heart, lung & circulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kazi, Samia N.</au><au>Von Huben, Amy</au><au>Marschner, Simone</au><au>Chong, James J.H.</au><au>Denniss, Alan Robert</au><au>Ong, Andrew T.L.</au><au>Chow, Clara K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trends in Modifiable Risk Factors Amongst First Presentation ST Elevation Myocardial Infarction Patients in a Large Longitudinal Registry</atitle><jtitle>Heart, lung & circulation</jtitle><addtitle>Heart Lung Circ</addtitle><date>2023-04</date><risdate>2023</risdate><volume>32</volume><issue>4</issue><spage>480</spage><epage>486</epage><pages>480-486</pages><issn>1443-9506</issn><eissn>1444-2892</eissn><abstract>Recent studies suggest that the risk factor profile of patients presenting with ST elevation myocardial infarction (STEMI) is changing.
The aim is to determine if there has been a shift of cardiovascular risk factors to cardiometabolic causes in the first presentation STEMI population.
We analysed data from a STEMI registry from a large tertiary referral percutaneous coronary intervention centre to determine the prevalence and trends of the modifiable risk factors of hypertension, diabetes, smoking and hypercholesterolaemia.
Consecutive first presentation STEMI patients between January 2006 to December 2018.
Among the 2,366 patients included (mean age 59, SD 12.66, 80% male) the common risk factors were hypertension (47%), hypercholesterolaemia (47%) current smoking (42%) and diabetes (27%). Over the 13 years, patients with diabetes (20% to 26%, OR 1.09 per year, CI 1.06–1.11, p<0.001) and patients with no modifiable risk factors increased (9% to 17%, OR 1.08, CI 1.04–1.11, p<0.001). Concurrently there was a fall in prevalence of hypercholesterolaemia, (47% to 37%, OR 0.94 per year, CI 0.92–0.96, p<0.001) and smoking (44% to 41%, OR 0.94, CI 0.92–0.96, p<0.001) but no significant change in rates of hypertension (53% to 49%, OR 0.99, CI 0.97–1.01, p=0.25).
The risk factor profile of first presentation STEMI has changed over time with a reduction in smoking and a concurrent rise in patients with no traditional risk factors. This suggests the mechanism of STEMI may be changing and further investigation of potential causal factors is warranted for the prevention and management of cardiovascular disease.</abstract><cop>Australia</cop><pub>Elsevier B.V</pub><pmid>36801127</pmid><doi>10.1016/j.hlc.2022.12.012</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6976-5835</orcidid><orcidid>https://orcid.org/0000-0003-4693-0038</orcidid><orcidid>https://orcid.org/0000-0002-5484-9144</orcidid></addata></record> |
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| ispartof | Heart, lung & circulation, 2023-04, Vol.32 (4), p.480-486 |
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| source | ScienceDirect Freedom Collection |
| subjects | Cardiometabolic risk factors Cardiovascular diseases Diabetes Mellitus - epidemiology Female Heart disease risk factors Humans Hypercholesterolemia - complications Hypercholesterolemia - epidemiology Hypertension - complications Hypertension - epidemiology Male Middle Aged Myocardial infarction Percutaneous Coronary Intervention Registries Risk Factors ST elevation myocardial infarction ST Elevation Myocardial Infarction - diagnosis ST Elevation Myocardial Infarction - epidemiology Treatment Outcome |
| title | Trends in Modifiable Risk Factors Amongst First Presentation ST Elevation Myocardial Infarction Patients in a Large Longitudinal Registry |
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