Targeting immunoregulation for cardiac regeneration

Inducing endogenous cardiomyocyte proliferation and heart regeneration is a promising strategy to treat ischemic heart failure. The immune response has recently been considered critical in cardiac regeneration. Thus, targeting the immune response is a potent strategy to improve cardiac regeneration...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2023-04, Vol.177, p.1-8
Main Authors: Li, Ruopu, Xiang, Chenying, Li, Yixun, Nie, Yu
Format: Article
Language:English
Subjects:
Cell Proliferation
Cell transplantation
Heart - physiology
Heart Failure
Heart regeneration
Humans
Immune response
Inflammation
Interleukin-6
Myocardial Infarction - therapy
Myocardial injury
Myocytes, Cardiac - physiology
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Summary:Inducing endogenous cardiomyocyte proliferation and heart regeneration is a promising strategy to treat ischemic heart failure. The immune response has recently been considered critical in cardiac regeneration. Thus, targeting the immune response is a potent strategy to improve cardiac regeneration and repair after myocardial infarction. Here we reviewed the characteristics of the relationship between the postinjury immune response and heart regenerative capacity and summarized the latest studies focusing on inflammation and heart regeneration to identify potent targets of the immune response and strategies in the immune response to promote cardiac regeneration. •Acute immune response is mandatory for the initiation of cardiac regeneration in neonates.•Transplantation of pro-regenerative immune cells improves the outcome of cardiac repair.•IL-6 family cytokines actively regulate myocardium repair and are potent targets for cardiac regeneration.
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2023.02.003