Peptide‐based formula: Clinical applications and benefits

The use of enteral nutrition (EN) continues to increase given benefits. However, with this increase in use, it is also becoming evident that enteral feeding intolerance (EFI) is also quite prevalent, leading to the inability to meet nutrition needs in many patients. Given the wide variability in the...

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Bibliographic Details
Published in:Nutrition in clinical practice 2023-04, Vol.38 (2), p.318-328
Main Authors: Mohamed Elfadil, Osman, Shah, Raj N., Hurt, Ryan T., Mundi, Manpreet S.
Format: Article
Language:English
Subjects:
Enteral Nutrition
Food, Formulated
formulas
Humans
Infant, Newborn
nutrition support
Nutritional Status
peptides
Peptides - therapeutic use
Triglycerides
tube feeding
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Summary:The use of enteral nutrition (EN) continues to increase given benefits. However, with this increase in use, it is also becoming evident that enteral feeding intolerance (EFI) is also quite prevalent, leading to the inability to meet nutrition needs in many patients. Given the wide variability in the EN population as well as the number of formulas available, there is not a clear consensus regarding the best approach to EFI management. One approach that is emerging to improve EN tolerance is the use of peptide‐based formulas (PBFs). PBFs refer to enteral formulas containing proteins that have been enzymatically hydrolyzed to dipeptides and tripeptides. These hydrolyzed proteins are often combined with higher medium‐chain triglyceride content to generate an enteral formula that is essentially easier to absorb and utilize. Emerging data demonstrate that the use of PBF in patients with EFI may improve clinical outcomes along with a corresponding reduction in healthcare utilization and potentially the cost of care. This review aims to navigate through key clinical applications and benefits of PBF and to discuss relevant data shared in the literature.
ISSN:0884-5336
1941-2452
DOI:10.1002/ncp.10961