MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration

Cancer cell proliferation is a high energy demanding process, where the cancer cells acquire energy by high rates of glycolysis, and this phenomenon is known as the “Warburg effect”. Microrchidia 2 (MORC2), an emerging chromatin remodeler, is over expressed in several cancers including breast cancer...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2023-02, Vol.40 (3), p.102-102, Article 102
Main Authors: Guddeti, Rohith Kumar, Pacharla, Himavani, Yellapu, Nanda Kumar, Karyala, Prashanthi, Pakala, Suresh B.
Format: Article
Language:English
Subjects:
Breast cancer
Breast Neoplasms - genetics
Cell growth
Cell Line, Tumor
Cell Proliferation - genetics
Enzymes
Female
Glucose
Glycolysis
Hematology
Humans
Internal Medicine
Medicine
Medicine & Public Health
Metabolism
Oncology
Original Paper
Pathology
Transcription Factors - genetics
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Summary:Cancer cell proliferation is a high energy demanding process, where the cancer cells acquire energy by high rates of glycolysis, and this phenomenon is known as the “Warburg effect”. Microrchidia 2 (MORC2), an emerging chromatin remodeler, is over expressed in several cancers including breast cancer and found to promote cancer cell proliferation. However, the role of MORC2 in glucose metabolism in cancer cells remains unexplored. In this study, we report that MORC2 interacts indirectly with the genes involved in glucose metabolism via transcription factors MAX (MYC-associated factor X) and MYC. We also found that MORC2 co-localizes and interacts with MAX. Further, we observed a positive correlation of expression of MORC2 with glycolytic enzymes Hexokinase 1 (HK1), Lactate dehydrogenase A (LDHA) and Phosphofructokinase platelet (PFKP) type in multiple cancers. Surprisingly, the knockdown of either MORC2 or MAX not only decreased the expression of glycolytic enzymes but also inhibited breast cancer cell proliferation and migration. Together, these results demonstrate the involvement of the MORC2/MAX signaling axis in the expression of glycolytic enzymes and breast cancer cell proliferation and migration.
ISSN:1559-131X
1357-0560
1559-131X
DOI:10.1007/s12032-023-01974-2