Risk of type 2 diabetes mellitus between adolescents with antidepressant-resistant and antidepressant-responsive depression: A cohort study of 15,651 adolescents

• Published in: Journal of affective disorders 2023-05, Vol.328, p.210-214
• Main Authors: Hsu, Ju-Wei, Chen, Li-Chi, Huang, Kai-Lin, Tsai, Shih-Jen, Bai, Ya-Mei, Su, Tung-Ping, Chen, Tzeng-Ji, Chen, Mu-Hong
• Format: Article
• Language: English
• Subjects: Adolescent; Adolescent depression; Antidepressant-resistant depression; Antidepressant-responsive depression; Antidepressive Agents; Cohort Studies; Depression; Diabetes Mellitus, Type 2 - etiology; Humans; Risk Factors; Type 2 diabetes mellitus
• ISSN: 0165-0327; 1573-2517
• DOI: 10.1016/j.jad.2023.02.065

Whether response to antidepressants is related to the risk of developing type 2 diabetes mellitus (T2DM) in adolescents with depression remains unknown. This study used the Taiwan National Health Insurance Research Database to enroll 1739 adolescents with antidepressant-resistant depression, 6956 with antidepressant-responsive depression, and 6956 controls between 2001 and 2010, with an end-of-2011 follow-up. Physician-diagnosed T2DM was identified at follow-up. T2DM-related risk factors, namely hypertension, dyslipidemia, and obesity, were assessed and controlled for as confounding factors. Adolescents with antidepressant-resistant depression (hazard ratio [HR], 95 % confidence interval [CI]: 4.62, 2.75–7.75) and those with antidepressant-responsive depression (HR, 95 % CI: 3.06, 1.98–4.72) had a higher risk of developing T2DM at follow-up than did the control group. Those with antidepressant-resistant depression were more likely to receive a diagnosis of T2DM (HR, 95 % CI: 1.51, 1.04–2.19) later in life than were those with antidepressant-responsive depression. Clinicians should closely monitor factors related to T2DM, such as fasting blood sugar, in high-risk populations, especially in adolescents with antidepressant-resistant depression. •Adolescent depression was a risk factor for T2DM development during the follow-up.•Adolescents with antidepressant (ATD)-resistant depression had an increased T2DM risk compared with ATD-responsive depression group.•Clinicians should closely monitor risk factors related to T2DM especially in adolescents with ATD-resistant depression.