Differences in sexual adverse events for premature ejaculation medications from a public federal database

American Urological Association (AUA) guidelines recommend selective serotonin reuptake inhibitors (SSRI) as first-line pharmacotherapy for premature ejaculation (PE). While previous studies have described sexual adverse events (AE) associated with each medication, there is limited data directly com...

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Bibliographic Details
Published in:International journal of impotence research 2024-08, Vol.36 (5), p.515-520
Main Authors: Tram, Michael, Meyerson, Brian, Welliver, Charles, Inouye, Brian
Format: Article
Language:English
Subjects:
692/700/565/1436
692/700/565/2194
Drug dosages
Erectile dysfunction
Fatigue
Medicine
Medicine & Public Health
Orgasm
Patients
Reproductive Medicine
rology
Self destructive behavior
Sexual disorders
Side effects
Statistical analysis
Urology
Citations: Items that this one cites
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Summary:American Urological Association (AUA) guidelines recommend selective serotonin reuptake inhibitors (SSRI) as first-line pharmacotherapy for premature ejaculation (PE). While previous studies have described sexual adverse events (AE) associated with each medication, there is limited data directly comparing rates of specific sexual AEs across SSRIs. This study investigates the Food and Drug Administration Adverse Event Reporting System (FAERS) database for reports of monotherapy use of fluoxetine 20 mg, paroxetine 20 mg, sertraline 50 mg, and sertraline 100 mg in males from January 2004–June 2021. We examined 2608 reports from patients using SSRIs for PE or other psychiatric conditions. The average number of AEs was significantly different ( p  
ISSN:0955-9930
1476-5489
1476-5489
DOI:10.1038/s41443-023-00676-7