Fabrication and characterization of PVA@PLA electrospinning nanofibers embedded with Bletilla striata polysaccharide and Rosmarinic acid to promote wound healing

In this study, a novel nanofiber material with Polylactic acid (PLA), natural plant polysaccharides-Bletilla striata polysaccharide (BSP) and Rosmarinic acid (RA) as the raw materials to facilitate wound healing was well prepared through coaxial electrospinning. The morphology of RA-BSP-PVA@PLA nano...

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Bibliographic Details
Published in:International journal of biological macromolecules 2023-04, Vol.234, p.123693-123693, Article 123693
Main Authors: Zhong, Guofeng, Qiu, Mengyu, Zhang, Junbo, Jiang, Fuchen, Yue, Xuan, Huang, Chi, Zhao, Shiyi, Zeng, Rui, Zhang, Chen, Qu, Yan
Format: Article
Language:English
Subjects:
Animals
Bletilla striata polysaccharide
Coaxial electrospinning
Nanofibers - chemistry
Orchidaceae - chemistry
Polyesters - chemistry
Polysaccharides - chemistry
Polysaccharides - pharmacology
Polyvinyl Alcohol - chemistry
Rats
Rosmarinic Acid
Wound dressing
Wound Healing
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Summary:In this study, a novel nanofiber material with Polylactic acid (PLA), natural plant polysaccharides-Bletilla striata polysaccharide (BSP) and Rosmarinic acid (RA) as the raw materials to facilitate wound healing was well prepared through coaxial electrospinning. The morphology of RA-BSP-PVA@PLA nanofibers was characterized through scanning electron microscopy (SEM), and the successful formation of core-shell structure was verified under confocal laser microscopy (CLSM) and Fourier transform infrared spectroscopy (FTIR). RA-BSP-PVA@PLA exhibited suitable air permeability for wound healing, as indicated by the result of the water vapor permeability (WVTR) study. The results of tension test results indicated the RA-BSP-PVA@PLA nanofiber exhibited excellent flexibility and better accommodates wounds. Moreover, the biocompatibility of RA-BSP-PVA@PLA was examined through MTT assay. Lastly, RA-BSP-PVA@PLA nanofibers can induce wound tissue growth, as verified by the rat dorsal skin wound models and tissue sections. Furthermore, RA-BSP-PVA@PLA can facilitate the proliferation and transformation of early wound macrophages, and down-regulate MPO+ expression of on the wound, thus facilitating wound healing, as confirmed by the result of immunohistochemical. Thus, RA-BSP-PVA@PLA nanofibers show great potential as wound dressings in wound healing.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.123693