Impact of D2 Gastrectomy for Locally Advanced Gastric Cancer in the Era of Effective Adjuvant Chemotherapy

Background Gastrectomy with D2 dissection has been established as the standard procedure for locally advanced gastric cancer in the era of surgery alone. However, no consideration has been given to the efficacy of dissection in the era of effective adjuvant chemotherapy. Methods This study included...

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Bibliographic Details
Published in:World journal of surgery 2023-06, Vol.47 (6), p.1512-1518
Main Authors: Yamagata, Yukinori, Yoshikawa, Takaki, Ishizu, Kenichi, Tsutsui, Mai, Wada, Takeyuki, Hayashi, Tsutomu
Format: Article
Language:English
Subjects:
Abdominal Surgery
Blood
Cancer
Cardiac Surgery
Chemotherapy
Chemotherapy, Adjuvant
Confidence intervals
Dissection
Gastrectomy
Gastrectomy - methods
Gastric cancer
Gastrointestinal surgery
General Surgery
Humans
Lymph Node Excision - methods
Medicine
Medicine & Public Health
Original Scientific Report
Retrospective Studies
Stomach Neoplasms - drug therapy
Stomach Neoplasms - surgery
Surgery
Survival
Thoracic Surgery
Vascular Surgery
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Summary:Background Gastrectomy with D2 dissection has been established as the standard procedure for locally advanced gastric cancer in the era of surgery alone. However, no consideration has been given to the efficacy of dissection in the era of effective adjuvant chemotherapy. Methods This study included 1298 advanced gastric cancer patients, consisting of 725 cases treated between January 2000 and December 2006 (Former group), and 573 cases treated between January 2007 and July 2015 (Latter group). Clinicopathological data were collected, survival and the therapeutic value index were determined. Results The background characteristics were well balanced, except for age, tumor location, and intraoperative blood loss. The Latter group showed the following characteristics: an older population ( p  
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-023-06934-5