Prognostic value and clinicopathological status of PD‐L1 expression and CD8+ TILs in oral squamous cell cancer patients with or without traditional risk factors

Background Non‐smokers, non‐drinkers, and non‐betel quid chewers (NSNDNBs) with oral squamous cell carcinoma (OSCC) have poor survival outcomes. Tumor microenvironment based on PD‐L1/CD8+ T cell infiltrated lymphocyte (TIL) proportion is proposed as a prognostic indicator. Methods Immunohistochemist...

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Published in:Head & neck 2023-04, Vol.45 (4), p.1017-1025
Main Authors: Soopanit, Thanion, Laokulrath, Natthawadee, Chayopasakul, Veeruth, Pongsapich, Warut
Format: Article
Language:English
Subjects:
B7-H1 Antigen - metabolism
Carcinoma, Squamous Cell - pathology
CD8 antigen
CD8 tumor‐infiltrating lymphocytes
CD8-Positive T-Lymphocytes - metabolism
Female
Head and Neck Neoplasms - pathology
Humans
Immunohistochemistry
Lymphocytes T
Metastases
Mouth Neoplasms - pathology
Mouth Neoplasms - therapy
non‐betel quid chewer
non‐drinker
non‐smoker
Oral carcinoma
oral squamous cell cancer
Oral squamous cell carcinoma
PD-L1 protein
PD‐L1
Prognosis
Risk Factors
smoker and/or drinker and/or betel quid chewer
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck - pathology
Tumor Microenvironment
Tumors
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Summary:Background Non‐smokers, non‐drinkers, and non‐betel quid chewers (NSNDNBs) with oral squamous cell carcinoma (OSCC) have poor survival outcomes. Tumor microenvironment based on PD‐L1/CD8+ T cell infiltrated lymphocyte (TIL) proportion is proposed as a prognostic indicator. Methods Immunohistochemistry staining was performed on OSCC samples from 64 patients. The PD‐L1/CD8+ TILs were scored and stratified into four groups. Disease‐free survival (DFS) was analyzed using a Cox regression model. Results OSCC in NSNDNB patients was associated with female sex, T1‐2 classification, and PD‐L1 positivity. Low CD8+ TILs correlated with perineural invasion. High CD8+ TILs correlated with improved DFS. PD‐L1 positivity was not correlated with DFS. Type IV tumor microenvironment yielded the highest DFS (85%). Conclusion NSNDNB status relates to PD‐L1 expression regardless of CD8+ TILs infiltration. Type IV tumor microenvironment was associated with the best DFS. High CD8+ TILs resulted in better survival, while PD‐L1 positivity alone was not correlated to DFS.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.27330