A multifunctional sateen woven dressings for treatment of skin injuries

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2023-04, Vol.224, p.113197-113197, Article 113197
• Main Authors: Ozel, Ceren, Apaydin, Elif, Sariboyaci, Ayla Eker, Tamayol, Ali, Avci, Huseyin
• Format: Article
• Language: English
• Subjects: Antimicrobial; Bandages; Biotextiles; Burns; Composite cell-laden fiber; Diabetes Mellitus; Humans; Mesenchymal stem cells; Skin; Staphylococcus aureus; Ulcer; Wound dressing
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2023.113197

Cutaneous wounds with impaired healing such as diabetic ulcers and burns constitute major and rapidly growing threat to healthcare systems worldwide. Accelerating wound healing requires the delivery of biological factors that induce angiogenesis, support cellular proliferation, and modulate inflammation while minimizing infection. In this study, we engineered a dressing made by weaving of composite fibers (CFs) carrying mesenchymal stem cells (MSCs) and a model antibiotic using a scalable sateen textile technique. In this regard, two different sets of CFs carrying MSCs or an antimicrobial agent were used to generate a multifunctional dressing. According to cell viability and metabolic activity as CCK-8 and live/dead with qRT-PCR results, more than %90 the encapsulated MSCs remain viable for 28 days and their expression levels of the wound repair factors including ECM remodeling, angiogenesis and immunomodulatory maintained in MSCs post dressing manufacturing for 14 days. Post 10 days culture of the dressing, MSCs within CFs had 10-fold higher collagen synthesis (p