Usefulness of the perfusion index for monitoring the response to intravenous ketamine infusion therapy in patients with complex regional pain syndrome

Background This study was performed to compare the perfusion index (PI) between affected and unaffected limbs in patients with complex regional pain syndrome (CRPS); it also evaluated the usefulness of the PI for monitoring the response to intravenous ketamine infusion therapy in such patients. Meth...

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Bibliographic Details
Published in:Pain practice 2023-06, Vol.23 (5), p.535-542
Main Authors: Hong, Seung‐Wan, Hwang, Min‐Sik, Kim, Jae Hun, Kim, Minjung, Kim, Seong‐Hyop
Format: Article
Language:English
Subjects:
Analgesics - therapeutic use
complex regional pain syndrome
Complex Regional Pain Syndromes - drug therapy
Complex Regional Pain Syndromes - etiology
Humans
Infusions, Intravenous
ketamine
Ketamine - therapeutic use
Perfusion Index
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Summary:Background This study was performed to compare the perfusion index (PI) between affected and unaffected limbs in patients with complex regional pain syndrome (CRPS); it also evaluated the usefulness of the PI for monitoring the response to intravenous ketamine infusion therapy in such patients. Methods In total, 46 patients with CRPS in one arm or leg were enrolled in this study. The PIs of the unaffected (PIControl) and affected (PICRPS) limbs were simultaneously evaluated before and after treatment. Results PICRPS was significantly lower than PIControl at all time points. The change in PI from immediately before to 30 min after intravenous ketamine infusion therapy (TBefore and T30 min, respectively) in the affected limb was significantly correlated with the change in visual analog pain scale (VAS) between the two time points (r = 0.646, p 
ISSN:1530-7085
1533-2500
DOI:10.1111/papr.13215