Loading…
Assessment of uremic toxins in advanced chronic kidney disease patients on maintenance hemodialysis by LC-ESI-MS/MS
Introduction In the advanced stage of chronic kidney disease (CKD), electrolytes, fluids, and metabolic wastes including various uremic toxins, accumulate at high concentrations in the patients’ blood. Hemodialysis (HD) is the conventional procedure used worldwide to remove metabolic wastes. The cre...
Saved in:
| Published in: | Metabolomics 2023-02, Vol.19 (3), p.14-14, Article 14 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c375t-7d9c57de123d34eaa3c9f7b1a2bda62595cb590beb73a456cf0f1494fcd8c2853 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c375t-7d9c57de123d34eaa3c9f7b1a2bda62595cb590beb73a456cf0f1494fcd8c2853 |
| container_end_page | 14 |
| container_issue | 3 |
| container_start_page | 14 |
| container_title | Metabolomics |
| container_volume | 19 |
| creator | Ragi, Nagarjunachary Pallerla, Pavankumar Babi Reddy Gari, Aravind Reddy Lingampelly, Sai Sachin Ketavarapu, Vijayasarathy Addipilli, Ramunaidu Chirra, Nagaraju Kantevari, Srinivas Yadla, Manjusha Sripadi, Prabhakar |
| description | Introduction
In the advanced stage of chronic kidney disease (CKD), electrolytes, fluids, and metabolic wastes including various uremic toxins, accumulate at high concentrations in the patients’ blood. Hemodialysis (HD) is the conventional procedure used worldwide to remove metabolic wastes. The creatinine and urea levels have been routinely monitored to estimate kidney function and effectiveness of the HD process. This study, first from in Indian perspective, aimed at the identification and quantification of major uremic toxins in CKD patients on maintenance HD (PRE-HD), and compared with the healthy controls (HC) as well as after HD (POST-HD).
Objectives
The study mainly focused on the identification of major uremic toxins in Indian perspective and the quantitative analysis of indoxyl sulfate and p-cresol sulfate (routinely targeted uremic toxins), and phenyl sulfate, catechol sulfate, and guaiacol sulfate (targeted for the first time), apart from creatinine and urea in PRE-HD, POST-HD, and HC groups.
Methods
Blood samples were collected from 90 HD patients (both PRE-HD and POST-HD), and 74 HCs. The plasma samples were subjected to direct ESI-HRMS and LC/HRMS for untargeted metabolomics and LC-MS/MS for quantitative analysis.
Results
Various known uremic toxins, and a few new and unknown peaks were detected in PRE-HD patients. The p-cresol sulfate and indoxyl sulfate were dominant in PRE-HD, the concentrations of phenyl sulfate, catechol sulfate, and guaiacol sulfate were about 50% of that of indoxyl sulfate. Statistical evaluation on the levels of targeted uremic toxins in PRE-HD, POST-HD, and HC groups showed a significant difference among the three groups. The dialytic clearance of indoxyl sulfate and p-cresol sulfate was found to be |
| doi_str_mv | 10.1007/s11306-023-01978-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2780070346</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2780070346</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-7d9c57de123d34eaa3c9f7b1a2bda62595cb590beb73a456cf0f1494fcd8c2853</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS0EoqXwAiyQJTZsTP0Tx_GyGpW20lQsBtaWY99Ql4k95CYV06fHZcqPWLCypfud4yt_hLwW_L3g3JyiEIq3jEvFuLCmY_dPyLHQRjHVWf70r_sReYF4y3nTWMOfkyPVdrJthT0meIYIiCPkmZaBLhOMKdC5fE8ZacrUxzufA0QabqaS6-hrihn2NCYEj0B3fk41i7RkOvqUZ8gPPL2BscTkt3tMSPs9Xa_Y-eaKXW9OrzcvybPBbxFePZ4n5POH80-rS7b-eHG1OluzoIyemYk2aBNBSBVVA96rYAfTCy_76FuprQ69tryH3ijf6DYMfBCNbYYQuyA7rU7Iu0PvbirfFsDZjQkDbLc-Q1nQSdPVb-SqaSv69h_0tixTrttVylhtpNGyUvJAhakgTjC43ZRGP-2d4O5BiTsocVWJ-6nE3dfQm8fqpR8h_o78clABdQCwjvIXmP68_Z_aHzlvmCs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2779572752</pqid></control><display><type>article</type><title>Assessment of uremic toxins in advanced chronic kidney disease patients on maintenance hemodialysis by LC-ESI-MS/MS</title><source>Springer Nature</source><creator>Ragi, Nagarjunachary ; Pallerla, Pavankumar ; Babi Reddy Gari, Aravind Reddy ; Lingampelly, Sai Sachin ; Ketavarapu, Vijayasarathy ; Addipilli, Ramunaidu ; Chirra, Nagaraju ; Kantevari, Srinivas ; Yadla, Manjusha ; Sripadi, Prabhakar</creator><creatorcontrib>Ragi, Nagarjunachary ; Pallerla, Pavankumar ; Babi Reddy Gari, Aravind Reddy ; Lingampelly, Sai Sachin ; Ketavarapu, Vijayasarathy ; Addipilli, Ramunaidu ; Chirra, Nagaraju ; Kantevari, Srinivas ; Yadla, Manjusha ; Sripadi, Prabhakar</creatorcontrib><description>Introduction
In the advanced stage of chronic kidney disease (CKD), electrolytes, fluids, and metabolic wastes including various uremic toxins, accumulate at high concentrations in the patients’ blood. Hemodialysis (HD) is the conventional procedure used worldwide to remove metabolic wastes. The creatinine and urea levels have been routinely monitored to estimate kidney function and effectiveness of the HD process. This study, first from in Indian perspective, aimed at the identification and quantification of major uremic toxins in CKD patients on maintenance HD (PRE-HD), and compared with the healthy controls (HC) as well as after HD (POST-HD).
Objectives
The study mainly focused on the identification of major uremic toxins in Indian perspective and the quantitative analysis of indoxyl sulfate and p-cresol sulfate (routinely targeted uremic toxins), and phenyl sulfate, catechol sulfate, and guaiacol sulfate (targeted for the first time), apart from creatinine and urea in PRE-HD, POST-HD, and HC groups.
Methods
Blood samples were collected from 90 HD patients (both PRE-HD and POST-HD), and 74 HCs. The plasma samples were subjected to direct ESI-HRMS and LC/HRMS for untargeted metabolomics and LC-MS/MS for quantitative analysis.
Results
Various known uremic toxins, and a few new and unknown peaks were detected in PRE-HD patients. The p-cresol sulfate and indoxyl sulfate were dominant in PRE-HD, the concentrations of phenyl sulfate, catechol sulfate, and guaiacol sulfate were about 50% of that of indoxyl sulfate. Statistical evaluation on the levels of targeted uremic toxins in PRE-HD, POST-HD, and HC groups showed a significant difference among the three groups. The dialytic clearance of indoxyl sulfate and p-cresol sulfate was found to be < 35%, while that of the other three sulfates was 50–58%.
Conclusion
LC-MS/MS method was developed and validated to evaluate five major uremic toxins in CKD patients on HD. The levels of the targeted uremic toxins could be used to assess kidney function and the effectiveness of HD.</description><identifier>ISSN: 1573-3890</identifier><identifier>ISSN: 1573-3882</identifier><identifier>EISSN: 1573-3890</identifier><identifier>DOI: 10.1007/s11306-023-01978-z</identifier><identifier>PMID: 36826619</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Catechol ; Cell Biology ; Chromatography, Liquid ; Creatinine ; Cresol ; Developmental Biology ; Guaiacol ; Hemodialysis ; Humans ; Indican - metabolism ; Kidney diseases ; Life Sciences ; Metabolism ; Metabolomics ; Molecular Medicine ; Original Article ; p-Cresol ; Quantitative analysis ; Renal Dialysis ; Renal Insufficiency, Chronic - metabolism ; Sulfates ; Tandem Mass Spectrometry ; Urea ; Uremic Toxins</subject><ispartof>Metabolomics, 2023-02, Vol.19 (3), p.14-14, Article 14</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-7d9c57de123d34eaa3c9f7b1a2bda62595cb590beb73a456cf0f1494fcd8c2853</citedby><cites>FETCH-LOGICAL-c375t-7d9c57de123d34eaa3c9f7b1a2bda62595cb590beb73a456cf0f1494fcd8c2853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36826619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ragi, Nagarjunachary</creatorcontrib><creatorcontrib>Pallerla, Pavankumar</creatorcontrib><creatorcontrib>Babi Reddy Gari, Aravind Reddy</creatorcontrib><creatorcontrib>Lingampelly, Sai Sachin</creatorcontrib><creatorcontrib>Ketavarapu, Vijayasarathy</creatorcontrib><creatorcontrib>Addipilli, Ramunaidu</creatorcontrib><creatorcontrib>Chirra, Nagaraju</creatorcontrib><creatorcontrib>Kantevari, Srinivas</creatorcontrib><creatorcontrib>Yadla, Manjusha</creatorcontrib><creatorcontrib>Sripadi, Prabhakar</creatorcontrib><title>Assessment of uremic toxins in advanced chronic kidney disease patients on maintenance hemodialysis by LC-ESI-MS/MS</title><title>Metabolomics</title><addtitle>Metabolomics</addtitle><addtitle>Metabolomics</addtitle><description>Introduction
In the advanced stage of chronic kidney disease (CKD), electrolytes, fluids, and metabolic wastes including various uremic toxins, accumulate at high concentrations in the patients’ blood. Hemodialysis (HD) is the conventional procedure used worldwide to remove metabolic wastes. The creatinine and urea levels have been routinely monitored to estimate kidney function and effectiveness of the HD process. This study, first from in Indian perspective, aimed at the identification and quantification of major uremic toxins in CKD patients on maintenance HD (PRE-HD), and compared with the healthy controls (HC) as well as after HD (POST-HD).
Objectives
The study mainly focused on the identification of major uremic toxins in Indian perspective and the quantitative analysis of indoxyl sulfate and p-cresol sulfate (routinely targeted uremic toxins), and phenyl sulfate, catechol sulfate, and guaiacol sulfate (targeted for the first time), apart from creatinine and urea in PRE-HD, POST-HD, and HC groups.
Methods
Blood samples were collected from 90 HD patients (both PRE-HD and POST-HD), and 74 HCs. The plasma samples were subjected to direct ESI-HRMS and LC/HRMS for untargeted metabolomics and LC-MS/MS for quantitative analysis.
Results
Various known uremic toxins, and a few new and unknown peaks were detected in PRE-HD patients. The p-cresol sulfate and indoxyl sulfate were dominant in PRE-HD, the concentrations of phenyl sulfate, catechol sulfate, and guaiacol sulfate were about 50% of that of indoxyl sulfate. Statistical evaluation on the levels of targeted uremic toxins in PRE-HD, POST-HD, and HC groups showed a significant difference among the three groups. The dialytic clearance of indoxyl sulfate and p-cresol sulfate was found to be < 35%, while that of the other three sulfates was 50–58%.
Conclusion
LC-MS/MS method was developed and validated to evaluate five major uremic toxins in CKD patients on HD. The levels of the targeted uremic toxins could be used to assess kidney function and the effectiveness of HD.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Catechol</subject><subject>Cell Biology</subject><subject>Chromatography, Liquid</subject><subject>Creatinine</subject><subject>Cresol</subject><subject>Developmental Biology</subject><subject>Guaiacol</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Indican - metabolism</subject><subject>Kidney diseases</subject><subject>Life Sciences</subject><subject>Metabolism</subject><subject>Metabolomics</subject><subject>Molecular Medicine</subject><subject>Original Article</subject><subject>p-Cresol</subject><subject>Quantitative analysis</subject><subject>Renal Dialysis</subject><subject>Renal Insufficiency, Chronic - metabolism</subject><subject>Sulfates</subject><subject>Tandem Mass Spectrometry</subject><subject>Urea</subject><subject>Uremic Toxins</subject><issn>1573-3890</issn><issn>1573-3882</issn><issn>1573-3890</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhS0EoqXwAiyQJTZsTP0Tx_GyGpW20lQsBtaWY99Ql4k95CYV06fHZcqPWLCypfud4yt_hLwW_L3g3JyiEIq3jEvFuLCmY_dPyLHQRjHVWf70r_sReYF4y3nTWMOfkyPVdrJthT0meIYIiCPkmZaBLhOMKdC5fE8ZacrUxzufA0QabqaS6-hrihn2NCYEj0B3fk41i7RkOvqUZ8gPPL2BscTkt3tMSPs9Xa_Y-eaKXW9OrzcvybPBbxFePZ4n5POH80-rS7b-eHG1OluzoIyemYk2aBNBSBVVA96rYAfTCy_76FuprQ69tryH3ijf6DYMfBCNbYYQuyA7rU7Iu0PvbirfFsDZjQkDbLc-Q1nQSdPVb-SqaSv69h_0tixTrttVylhtpNGyUvJAhakgTjC43ZRGP-2d4O5BiTsocVWJ-6nE3dfQm8fqpR8h_o78clABdQCwjvIXmP68_Z_aHzlvmCs</recordid><startdate>20230224</startdate><enddate>20230224</enddate><creator>Ragi, Nagarjunachary</creator><creator>Pallerla, Pavankumar</creator><creator>Babi Reddy Gari, Aravind Reddy</creator><creator>Lingampelly, Sai Sachin</creator><creator>Ketavarapu, Vijayasarathy</creator><creator>Addipilli, Ramunaidu</creator><creator>Chirra, Nagaraju</creator><creator>Kantevari, Srinivas</creator><creator>Yadla, Manjusha</creator><creator>Sripadi, Prabhakar</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20230224</creationdate><title>Assessment of uremic toxins in advanced chronic kidney disease patients on maintenance hemodialysis by LC-ESI-MS/MS</title><author>Ragi, Nagarjunachary ; Pallerla, Pavankumar ; Babi Reddy Gari, Aravind Reddy ; Lingampelly, Sai Sachin ; Ketavarapu, Vijayasarathy ; Addipilli, Ramunaidu ; Chirra, Nagaraju ; Kantevari, Srinivas ; Yadla, Manjusha ; Sripadi, Prabhakar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-7d9c57de123d34eaa3c9f7b1a2bda62595cb590beb73a456cf0f1494fcd8c2853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Catechol</topic><topic>Cell Biology</topic><topic>Chromatography, Liquid</topic><topic>Creatinine</topic><topic>Cresol</topic><topic>Developmental Biology</topic><topic>Guaiacol</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Indican - metabolism</topic><topic>Kidney diseases</topic><topic>Life Sciences</topic><topic>Metabolism</topic><topic>Metabolomics</topic><topic>Molecular Medicine</topic><topic>Original Article</topic><topic>p-Cresol</topic><topic>Quantitative analysis</topic><topic>Renal Dialysis</topic><topic>Renal Insufficiency, Chronic - metabolism</topic><topic>Sulfates</topic><topic>Tandem Mass Spectrometry</topic><topic>Urea</topic><topic>Uremic Toxins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ragi, Nagarjunachary</creatorcontrib><creatorcontrib>Pallerla, Pavankumar</creatorcontrib><creatorcontrib>Babi Reddy Gari, Aravind Reddy</creatorcontrib><creatorcontrib>Lingampelly, Sai Sachin</creatorcontrib><creatorcontrib>Ketavarapu, Vijayasarathy</creatorcontrib><creatorcontrib>Addipilli, Ramunaidu</creatorcontrib><creatorcontrib>Chirra, Nagaraju</creatorcontrib><creatorcontrib>Kantevari, Srinivas</creatorcontrib><creatorcontrib>Yadla, Manjusha</creatorcontrib><creatorcontrib>Sripadi, Prabhakar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ragi, Nagarjunachary</au><au>Pallerla, Pavankumar</au><au>Babi Reddy Gari, Aravind Reddy</au><au>Lingampelly, Sai Sachin</au><au>Ketavarapu, Vijayasarathy</au><au>Addipilli, Ramunaidu</au><au>Chirra, Nagaraju</au><au>Kantevari, Srinivas</au><au>Yadla, Manjusha</au><au>Sripadi, Prabhakar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of uremic toxins in advanced chronic kidney disease patients on maintenance hemodialysis by LC-ESI-MS/MS</atitle><jtitle>Metabolomics</jtitle><stitle>Metabolomics</stitle><addtitle>Metabolomics</addtitle><date>2023-02-24</date><risdate>2023</risdate><volume>19</volume><issue>3</issue><spage>14</spage><epage>14</epage><pages>14-14</pages><artnum>14</artnum><issn>1573-3890</issn><issn>1573-3882</issn><eissn>1573-3890</eissn><abstract>Introduction
In the advanced stage of chronic kidney disease (CKD), electrolytes, fluids, and metabolic wastes including various uremic toxins, accumulate at high concentrations in the patients’ blood. Hemodialysis (HD) is the conventional procedure used worldwide to remove metabolic wastes. The creatinine and urea levels have been routinely monitored to estimate kidney function and effectiveness of the HD process. This study, first from in Indian perspective, aimed at the identification and quantification of major uremic toxins in CKD patients on maintenance HD (PRE-HD), and compared with the healthy controls (HC) as well as after HD (POST-HD).
Objectives
The study mainly focused on the identification of major uremic toxins in Indian perspective and the quantitative analysis of indoxyl sulfate and p-cresol sulfate (routinely targeted uremic toxins), and phenyl sulfate, catechol sulfate, and guaiacol sulfate (targeted for the first time), apart from creatinine and urea in PRE-HD, POST-HD, and HC groups.
Methods
Blood samples were collected from 90 HD patients (both PRE-HD and POST-HD), and 74 HCs. The plasma samples were subjected to direct ESI-HRMS and LC/HRMS for untargeted metabolomics and LC-MS/MS for quantitative analysis.
Results
Various known uremic toxins, and a few new and unknown peaks were detected in PRE-HD patients. The p-cresol sulfate and indoxyl sulfate were dominant in PRE-HD, the concentrations of phenyl sulfate, catechol sulfate, and guaiacol sulfate were about 50% of that of indoxyl sulfate. Statistical evaluation on the levels of targeted uremic toxins in PRE-HD, POST-HD, and HC groups showed a significant difference among the three groups. The dialytic clearance of indoxyl sulfate and p-cresol sulfate was found to be < 35%, while that of the other three sulfates was 50–58%.
Conclusion
LC-MS/MS method was developed and validated to evaluate five major uremic toxins in CKD patients on HD. The levels of the targeted uremic toxins could be used to assess kidney function and the effectiveness of HD.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36826619</pmid><doi>10.1007/s11306-023-01978-z</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1573-3890 |
| ispartof | Metabolomics, 2023-02, Vol.19 (3), p.14-14, Article 14 |
| issn | 1573-3890 1573-3882 1573-3890 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2780070346 |
| source | Springer Nature |
| subjects | Biochemistry Biomedical and Life Sciences Biomedicine Catechol Cell Biology Chromatography, Liquid Creatinine Cresol Developmental Biology Guaiacol Hemodialysis Humans Indican - metabolism Kidney diseases Life Sciences Metabolism Metabolomics Molecular Medicine Original Article p-Cresol Quantitative analysis Renal Dialysis Renal Insufficiency, Chronic - metabolism Sulfates Tandem Mass Spectrometry Urea Uremic Toxins |
| title | Assessment of uremic toxins in advanced chronic kidney disease patients on maintenance hemodialysis by LC-ESI-MS/MS |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T02%3A16%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20uremic%20toxins%20in%20advanced%20chronic%20kidney%20disease%20patients%20on%20maintenance%20hemodialysis%20by%20LC-ESI-MS/MS&rft.jtitle=Metabolomics&rft.au=Ragi,%20Nagarjunachary&rft.date=2023-02-24&rft.volume=19&rft.issue=3&rft.spage=14&rft.epage=14&rft.pages=14-14&rft.artnum=14&rft.issn=1573-3890&rft.eissn=1573-3890&rft_id=info:doi/10.1007/s11306-023-01978-z&rft_dat=%3Cproquest_cross%3E2780070346%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c375t-7d9c57de123d34eaa3c9f7b1a2bda62595cb590beb73a456cf0f1494fcd8c2853%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2779572752&rft_id=info:pmid/36826619&rfr_iscdi=true |