Fulminant mpox as an AIDS-defining condition: useful or stigmatising?

[...]pulmonary involvement was more common and CNS involvement was almost exclusively detected among individuals with very low CD4 cell counts. [...]of those who developed immune reconstitution inflammatory syndrome, 12 (57%) died.8 This finding raises the question about the timing of ART initiation...

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Bibliographic Details
Published in:The Lancet (British edition) 2023-03, Vol.401 (10380), p.881-884
Main Authors: Núñez, Isaac, Valdés-Ferrer, Sergio Iván
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome
AIDS
Antiretroviral therapy
CD4 antigen
Disease transmission
HIV
Hospitals
Human immunodeficiency virus
Humans
Immune reconstitution
Infections
Inflammation
Labeling
Mpox
Mpox (monkeypox)
Public health
Sexually transmitted diseases
STD
Stigma
Vaccines
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Summary:[...]pulmonary involvement was more common and CNS involvement was almost exclusively detected among individuals with very low CD4 cell counts. [...]of those who developed immune reconstitution inflammatory syndrome, 12 (57%) died.8 This finding raises the question about the timing of ART initiation in people with newly diagnosed advanced HIV and concurrent fulminant mpox infection, and whether delaying ART could be the safer strategy. [...]the suspicion of mpox grants a thorough search for sexually transmitted diseases independently of HIV status or, in the case of people living with HIV, CD4 cell count.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(23)00333-1