Presence of retinopathy and incident kidney and cardiovascular events in type 2 diabetes with normoalbuminuria – A post-hoc analysis of the PRIORITY randomized clinical trial

Baseline diabetic retinopathy (DR) and risk of development of microalbuminuria, kidney function decline, and cardiovascular events (CVEs) in type 2 diabetes. Post-hoc analysis of the PRIORITY study including 1758 persons with type 2 diabetes and normoalbuminuria followed for a median of 2.5 (IQR: 2....

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Published in:Journal of diabetes and its complications 2023-04, Vol.37 (4), p.108433-108433, Article 108433
Main Authors: Rotbain Curovic, Viktor, Tofte, Nete, Lindhardt, Morten, Adamova, Katarina, Bakker, Stephan J.L., Beige, Joachim, Beulens, Joline W.J., Birkenfeld, Andreas L., Currie, Gemma, Delles, Christian, Dimos, Ingo, Francová, Lidmila, Frimodt-Møller, Marie, Girman, Peter, Göke, Rüdiger, Hansen, Tine W., Havrdova, Tereza, Kooy, Adriaan, Laverman, Gozewijnw D., Mischak, Harald, Navis, Gerjan, Nijpels, Giel, Noutsou, Marina, Ortiz, Alberto, Parvanova, Aneliya, Persson, Frederik, Petrie, John R., Ruggenenti, Piero L., Rutters, Femke, Rychlík, Ivan, Siwy, Justyna, Spasovski, Goce, Speeckaert, Marijn, Trillini, Matias, Zürbig, Petra, von der Leyen, Heiko, Rossing, Peter
Format: Article
Language:English
Subjects:
Albuminuria
Albuminuria - complications
Cardiovascular disease
Chronic kidney disease
Clinical trials
Creatinine
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Diabetic Nephropathies
Diabetic retinopathy
Diabetic Retinopathy - complications
Diabetic Retinopathy - etiology
Endocrine system
Glomerular Filtration Rate
Heart failure
Humans
Industrialized nations
Kidney
Kidney diseases
Medical records
Peptides
Regression analysis
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - epidemiology
Risk stratification
Type 2 diabetes
Urine
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Summary:Baseline diabetic retinopathy (DR) and risk of development of microalbuminuria, kidney function decline, and cardiovascular events (CVEs) in type 2 diabetes. Post-hoc analysis of the PRIORITY study including 1758 persons with type 2 diabetes and normoalbuminuria followed for a median of 2.5 (IQR: 2.0–3.0) years. DR diagnosis included non-proliferative and proliferative abnormalities, macular oedema, or prior laser treatment. Cox models were fitted to investigate baseline DR presence with development of persistent microalbuminuria (urinary albumin-creatinine ratio > 30 mg/g); chronic kidney disease (CKD) G3 (eGFR
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2023.108433