Modification of oestrogen signalling pathways influences cough induced by citric acid but not capsaicin in the animal model of both sexes

• Published in: Respiratory physiology & neurobiology 2023-06, Vol.312, p.104039-104039, Article 104039
• Main Authors: Buday, Tomas, Matloobi, Alireza, Kopcova, Lucia, Brozmanova, Mariana, Sterusky, Miroslav, Plevkova, Jana
• Format: Article
• Language: English
• Subjects: Animals; Capsaicin - toxicity; Citric Acid - adverse effects; Cough; Cough - chemically induced; Danazol; Danazol - adverse effects; ERα; Estrogen Receptor alpha; Estrogens - pharmacology; Female; Fulvestrant; Fulvestrant - adverse effects; Guinea Pigs; Male; Models, Animal; Oestrogen
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2023.104039

To clarify the role of oestrogen signalling and the role of oestrogen receptor alpha (ERα) in the cough pathways we performed a study in which coughing was observed in both sexes animal models after the treatment by selective ERα degrader fulvestrant (ICI 182–780) and inhibitor of oestrogen synthesis danazol. Degradation of ERα with the normal plasma oestrogen levels induced by fulvestrant, significantly augments the cough response of female but not male guinea pigs. These changes were observed in citric acid-induced cough. Female guinea pigs responded with an increased count of cough expulsions per challenge time and we also detected shorter cough latency. The capsaicin-induced cough did not change. A similar response was observed after danazol treatment, which decreased the plasma oestrogen level. Our results indicate that the transient receptor potential vanilloid-1 (TRPV1) channel-mediated cough is resistant to the hypoestrous state, while the citric acid-mediated cough is oestrogen-dependent and hypersensitive during the hypoestrous state. •Cough induced by citric acid in female guinea pigs is sensitive to oestrogen.•Modulation of cough by oestrogen depends on ERα.•Capsaicin-induced cough via TRPV1 is oestrogen resistant.