Characteristics of synchronous and metachronous duodenal tumors and association with colorectal cancer: a supplementary analysis

• Published in: Journal of gastroenterology 2023-05, Vol.58 (5), p.459-469
• Main Authors: Yamasaki, Yasushi, Kato, Motohiko, Takeuchi, Yoji, Hoteya, Shu, Oyama, Tsuneo, Nonaka, Satoru, Yoshimizu, Shoichi, Yoshida, Masao, Ohata, Ken, Miura, Yoshimasa, Hara, Yuko, Tsuji, Shigetsugu, Dohi, Osamu, Ueyama, Hiroya, Kurahara, Koichi, Tashima, Tomoaki, Abe, Nobutsugu, Mitsuhashi, Toshiharu, Nakayama, Atsushi, Oda, Ichiro, Yahagi, Naohisa
• Format: Article
• Language: English
• Subjects: Abdominal Surgery; Analysis; Colonoscopy; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Colorectal Surgery; Duodenal Neoplasms - epidemiology; Duodenal Neoplasms - surgery; Endoscopy; Gastroenterology; Gastrointestinal diseases; Hepatology; Humans; Lesions; Medical colleges; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Neoplasms, Multiple Primary - epidemiology; Neoplasms, Second Primary - epidemiology; Neoplasms, Second Primary - pathology; Original Article—Alimentary Tract; Retrospective Studies; Risk Factors; Surgical Oncology; Tumors
• ISSN: 0944-1174; 1435-5922
• DOI: 10.1007/s00535-023-01964-1

Background We previously reported outcomes of endoscopic resection for duodenal tumors in a large cohort. This study investigated the frequency and characteristics of synchronous and metachronous lesions, and their association with colorectal advanced adenoma (CAA) and colorectal cancer (CRC). Methods Patients underwent duodenal endoscopic resection during January 2008 to December 2018. Background and characteristics, incidence of synchronous and metachronous lesions, and incidence of CAA and CRC were investigated. Patients without synchronous lesions were classified as the single group, and those with synchronous lesions as the synchronous group. Patients were also classified as the metachronous and non-metachronous groups. The characteristics among the groups were compared. Results We included 2658 patients with 2881 duodenal tumors: 2472 (93.0%) patients had single, 186 (7.0%) had synchronous, and 54 (2.0%) had metachronous lesions. The 5-year cumulative incidence of metachronous lesions was 4.1%. In total, 208 (7.8%) had CAA and 127 (4.8%) patients had CRC, and colonoscopy was performed in 936 (35.2%) patients. The incidence of CAA in the synchronous groups tended to be higher compared with that in the single groups (11.8% vs 7.5%, adjusted risk ratio 1.56), and the incidence of CRC in the metachronous groups tended to be higher compared with that in the non-metachronous groups (13.0% vs 4.6%, adjusted risk ratio 2.75), but there was no difference after adjusting for colonoscopy. Conclusions This study showed the incidence of synchronous and metachronous duodenal lesions. There was no significant difference in incidence of CAA and CRC among each group, but further studies are warranted.