Loading…
Bone mineral density, vertebral fractures and trabecular bone score in primary ovarian insufficiency
Purpose Bone health in primary ovarian insufficiency (POI) is under-investigated. We assessed patients with spontaneous POI for vertebral fractures (VFs) and related parameters of bone health. Methods 70 cases with spontaneous POI (age 32.5 ± 7.0 years) and an equal number of controls were assessed...
Saved in:
| Published in: | Journal of endocrinological investigation 2023-09, Vol.46 (9), p.1865-1874 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c326t-19ec7c07917b49310f218a6ad9f70d52931ebcf4e8133f24fb45c9fe5661fc043 |
| container_end_page | 1874 |
| container_issue | 9 |
| container_start_page | 1865 |
| container_title | Journal of endocrinological investigation |
| container_volume | 46 |
| creator | Dhakate, M. Goswami, D. Goswami, R. Saha, S. Kandasamy, D. Arora, M. |
| description | Purpose
Bone health in primary ovarian insufficiency (POI) is under-investigated. We assessed patients with spontaneous POI for vertebral fractures (VFs) and related parameters of bone health.
Methods
70 cases with spontaneous POI (age 32.5 ± 7.0 years) and an equal number of controls were assessed for BMD, TBS, and VFs. BMD at the lumbar-spine (L1-L4), left hip, non-dominant forearm, and TBS (iNsight software) were measured on a dual-energy X-ray absorptiometry (DXA) machine. VFs were assessed by Genant’s classification. Serum FSH, LH, estradiol, T4, TSH, iPTH, serum 25(OH)D, total calcium, and inorganic phosphorus were measured.
Results
BMD at the lumbar-spine, hip and forearm was reduced by 11.5%, 11.4% and 9.1% in POI as compared to controls (P |
| doi_str_mv | 10.1007/s40618-023-02045-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2780487964</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2780487964</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-19ec7c07917b49310f218a6ad9f70d52931ebcf4e8133f24fb45c9fe5661fc043</originalsourceid><addsrcrecordid>eNp9kUlPxCAcxYnROG5fwIMh8eLBKluBHtW4JSZe9Ewo_WM66VCF1mTm08s44xIPHgjk8XuP5SF0SMkZJUSdJ0Ek1QVhPA8iymKxgXaoYqTQXMvNX-sJ2k1pSghXXKttNOFSC02o3kHNZR8Az9oA0Xa4gZDaYX6K3yEOUC8lH60bxggJ29DgIdoa3NjZiOulMbk-Am4Dfo3tzMY57t9tbG3IUhq9b10Lwc330Za3XYKD9byHnm-un67uiofH2_uri4fCcSaHglbglCOqoqoWFafEM6qttE3lFWlKliWonRegKeeeCV-L0lUeSimpd0TwPXSyyn2N_dsIaTCzNjnoOhugH5NhShOhVSWX6PEfdNqPMeTbGaYFK4XQTGaKrSgX-5QieLN-p6HELDswqw5M7sB8dmAW2XS0jh7rGTTflq9PzwBfASlvhReIP2f_E_sBn1aTAg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2842544826</pqid></control><display><type>article</type><title>Bone mineral density, vertebral fractures and trabecular bone score in primary ovarian insufficiency</title><source>Springer Nature</source><creator>Dhakate, M. ; Goswami, D. ; Goswami, R. ; Saha, S. ; Kandasamy, D. ; Arora, M.</creator><creatorcontrib>Dhakate, M. ; Goswami, D. ; Goswami, R. ; Saha, S. ; Kandasamy, D. ; Arora, M.</creatorcontrib><description>Purpose
Bone health in primary ovarian insufficiency (POI) is under-investigated. We assessed patients with spontaneous POI for vertebral fractures (VFs) and related parameters of bone health.
Methods
70 cases with spontaneous POI (age 32.5 ± 7.0 years) and an equal number of controls were assessed for BMD, TBS, and VFs. BMD at the lumbar-spine (L1-L4), left hip, non-dominant forearm, and TBS (iNsight software) were measured on a dual-energy X-ray absorptiometry (DXA) machine. VFs were assessed by Genant’s classification. Serum FSH, LH, estradiol, T4, TSH, iPTH, serum 25(OH)D, total calcium, and inorganic phosphorus were measured.
Results
BMD at the lumbar-spine, hip and forearm was reduced by 11.5%, 11.4% and 9.1% in POI as compared to controls (P < 0.001). Degraded or partially degraded microarchitecture on TBS was observed in 66.7% of patients and 38.2% of controls (P = 0.001). 15.7% of the POI patients had VFs, compared to 4.3% of controls (P = 0.045). Age, duration of amenorrhea and duration of HRT use were the significant predictors of TBS (P < 0.01). Serum 25(OH)D was the significant determinant of VFs. TBS abnormalities were higher in patients with POI and VFs. BMD was not significantly different in patients with and without VFs.
Conclusion
Thus, lumbar-spine osteoporosis, impaired TBS and VFs were present in 35.7%, 66.7% and 15.7% of patients with spontaneous POI in their early third decade. This indicates need for rigorous investigations for impaired bone health in these young patients and management with HRT, vitamin-D, and possible need for bisphosphonate therapy.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-023-02045-z</identifier><identifier>PMID: 36848018</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>17β-Estradiol ; 25-Hydroxyvitamin D ; Amenorrhea ; Bone mineral density ; Cancellous bone ; Dual energy X-ray absorptiometry ; Endocrinology ; Follicle-stimulating hormone ; Forearm ; Fractures ; Hip ; Internal Medicine ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original Article ; Osteoporosis ; Ovaries ; Spine (lumbar) ; Vertebrae</subject><ispartof>Journal of endocrinological investigation, 2023-09, Vol.46 (9), p.1865-1874</ispartof><rights>The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-19ec7c07917b49310f218a6ad9f70d52931ebcf4e8133f24fb45c9fe5661fc043</cites><orcidid>0000-0002-3786-4924</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36848018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dhakate, M.</creatorcontrib><creatorcontrib>Goswami, D.</creatorcontrib><creatorcontrib>Goswami, R.</creatorcontrib><creatorcontrib>Saha, S.</creatorcontrib><creatorcontrib>Kandasamy, D.</creatorcontrib><creatorcontrib>Arora, M.</creatorcontrib><title>Bone mineral density, vertebral fractures and trabecular bone score in primary ovarian insufficiency</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Purpose
Bone health in primary ovarian insufficiency (POI) is under-investigated. We assessed patients with spontaneous POI for vertebral fractures (VFs) and related parameters of bone health.
Methods
70 cases with spontaneous POI (age 32.5 ± 7.0 years) and an equal number of controls were assessed for BMD, TBS, and VFs. BMD at the lumbar-spine (L1-L4), left hip, non-dominant forearm, and TBS (iNsight software) were measured on a dual-energy X-ray absorptiometry (DXA) machine. VFs were assessed by Genant’s classification. Serum FSH, LH, estradiol, T4, TSH, iPTH, serum 25(OH)D, total calcium, and inorganic phosphorus were measured.
Results
BMD at the lumbar-spine, hip and forearm was reduced by 11.5%, 11.4% and 9.1% in POI as compared to controls (P < 0.001). Degraded or partially degraded microarchitecture on TBS was observed in 66.7% of patients and 38.2% of controls (P = 0.001). 15.7% of the POI patients had VFs, compared to 4.3% of controls (P = 0.045). Age, duration of amenorrhea and duration of HRT use were the significant predictors of TBS (P < 0.01). Serum 25(OH)D was the significant determinant of VFs. TBS abnormalities were higher in patients with POI and VFs. BMD was not significantly different in patients with and without VFs.
Conclusion
Thus, lumbar-spine osteoporosis, impaired TBS and VFs were present in 35.7%, 66.7% and 15.7% of patients with spontaneous POI in their early third decade. This indicates need for rigorous investigations for impaired bone health in these young patients and management with HRT, vitamin-D, and possible need for bisphosphonate therapy.</description><subject>17β-Estradiol</subject><subject>25-Hydroxyvitamin D</subject><subject>Amenorrhea</subject><subject>Bone mineral density</subject><subject>Cancellous bone</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Endocrinology</subject><subject>Follicle-stimulating hormone</subject><subject>Forearm</subject><subject>Fractures</subject><subject>Hip</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original Article</subject><subject>Osteoporosis</subject><subject>Ovaries</subject><subject>Spine (lumbar)</subject><subject>Vertebrae</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kUlPxCAcxYnROG5fwIMh8eLBKluBHtW4JSZe9Ewo_WM66VCF1mTm08s44xIPHgjk8XuP5SF0SMkZJUSdJ0Ek1QVhPA8iymKxgXaoYqTQXMvNX-sJ2k1pSghXXKttNOFSC02o3kHNZR8Az9oA0Xa4gZDaYX6K3yEOUC8lH60bxggJ29DgIdoa3NjZiOulMbk-Am4Dfo3tzMY57t9tbG3IUhq9b10Lwc330Za3XYKD9byHnm-un67uiofH2_uri4fCcSaHglbglCOqoqoWFafEM6qttE3lFWlKliWonRegKeeeCV-L0lUeSimpd0TwPXSyyn2N_dsIaTCzNjnoOhugH5NhShOhVSWX6PEfdNqPMeTbGaYFK4XQTGaKrSgX-5QieLN-p6HELDswqw5M7sB8dmAW2XS0jh7rGTTflq9PzwBfASlvhReIP2f_E_sBn1aTAg</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Dhakate, M.</creator><creator>Goswami, D.</creator><creator>Goswami, R.</creator><creator>Saha, S.</creator><creator>Kandasamy, D.</creator><creator>Arora, M.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3786-4924</orcidid></search><sort><creationdate>20230901</creationdate><title>Bone mineral density, vertebral fractures and trabecular bone score in primary ovarian insufficiency</title><author>Dhakate, M. ; Goswami, D. ; Goswami, R. ; Saha, S. ; Kandasamy, D. ; Arora, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-19ec7c07917b49310f218a6ad9f70d52931ebcf4e8133f24fb45c9fe5661fc043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>17β-Estradiol</topic><topic>25-Hydroxyvitamin D</topic><topic>Amenorrhea</topic><topic>Bone mineral density</topic><topic>Cancellous bone</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Endocrinology</topic><topic>Follicle-stimulating hormone</topic><topic>Forearm</topic><topic>Fractures</topic><topic>Hip</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original Article</topic><topic>Osteoporosis</topic><topic>Ovaries</topic><topic>Spine (lumbar)</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dhakate, M.</creatorcontrib><creatorcontrib>Goswami, D.</creatorcontrib><creatorcontrib>Goswami, R.</creatorcontrib><creatorcontrib>Saha, S.</creatorcontrib><creatorcontrib>Kandasamy, D.</creatorcontrib><creatorcontrib>Arora, M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dhakate, M.</au><au>Goswami, D.</au><au>Goswami, R.</au><au>Saha, S.</au><au>Kandasamy, D.</au><au>Arora, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone mineral density, vertebral fractures and trabecular bone score in primary ovarian insufficiency</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>46</volume><issue>9</issue><spage>1865</spage><epage>1874</epage><pages>1865-1874</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Purpose
Bone health in primary ovarian insufficiency (POI) is under-investigated. We assessed patients with spontaneous POI for vertebral fractures (VFs) and related parameters of bone health.
Methods
70 cases with spontaneous POI (age 32.5 ± 7.0 years) and an equal number of controls were assessed for BMD, TBS, and VFs. BMD at the lumbar-spine (L1-L4), left hip, non-dominant forearm, and TBS (iNsight software) were measured on a dual-energy X-ray absorptiometry (DXA) machine. VFs were assessed by Genant’s classification. Serum FSH, LH, estradiol, T4, TSH, iPTH, serum 25(OH)D, total calcium, and inorganic phosphorus were measured.
Results
BMD at the lumbar-spine, hip and forearm was reduced by 11.5%, 11.4% and 9.1% in POI as compared to controls (P < 0.001). Degraded or partially degraded microarchitecture on TBS was observed in 66.7% of patients and 38.2% of controls (P = 0.001). 15.7% of the POI patients had VFs, compared to 4.3% of controls (P = 0.045). Age, duration of amenorrhea and duration of HRT use were the significant predictors of TBS (P < 0.01). Serum 25(OH)D was the significant determinant of VFs. TBS abnormalities were higher in patients with POI and VFs. BMD was not significantly different in patients with and without VFs.
Conclusion
Thus, lumbar-spine osteoporosis, impaired TBS and VFs were present in 35.7%, 66.7% and 15.7% of patients with spontaneous POI in their early third decade. This indicates need for rigorous investigations for impaired bone health in these young patients and management with HRT, vitamin-D, and possible need for bisphosphonate therapy.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36848018</pmid><doi>10.1007/s40618-023-02045-z</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3786-4924</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1720-8386 |
| ispartof | Journal of endocrinological investigation, 2023-09, Vol.46 (9), p.1865-1874 |
| issn | 1720-8386 0391-4097 1720-8386 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2780487964 |
| source | Springer Nature |
| subjects | 17β-Estradiol 25-Hydroxyvitamin D Amenorrhea Bone mineral density Cancellous bone Dual energy X-ray absorptiometry Endocrinology Follicle-stimulating hormone Forearm Fractures Hip Internal Medicine Medicine Medicine & Public Health Metabolic Diseases Original Article Osteoporosis Ovaries Spine (lumbar) Vertebrae |
| title | Bone mineral density, vertebral fractures and trabecular bone score in primary ovarian insufficiency |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T15%3A52%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bone%20mineral%20density,%20vertebral%20fractures%20and%20trabecular%20bone%20score%20in%20primary%20ovarian%20insufficiency&rft.jtitle=Journal%20of%20endocrinological%20investigation&rft.au=Dhakate,%20M.&rft.date=2023-09-01&rft.volume=46&rft.issue=9&rft.spage=1865&rft.epage=1874&rft.pages=1865-1874&rft.issn=1720-8386&rft.eissn=1720-8386&rft_id=info:doi/10.1007/s40618-023-02045-z&rft_dat=%3Cproquest_cross%3E2780487964%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c326t-19ec7c07917b49310f218a6ad9f70d52931ebcf4e8133f24fb45c9fe5661fc043%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2842544826&rft_id=info:pmid/36848018&rfr_iscdi=true |