Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria

Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two global epidemics that share several metabolic defects, such as insulin resistance, impaired glucose metabolism, and mitochondrial defects. Importantly, strong evidence demonstrates that T2D significantly increases the risk of cognitive...

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Bibliographic Details
Published in:Current opinion in neurobiology 2023-04, Vol.79, p.102694-102694, Article 102694
Main Authors: Carvalho, Cristina, Moreira, Paula I.
Format: Article
Language:English
Subjects:
Alzheimer Disease - pathology
Alzheimer's disease
Biomarkers - metabolism
diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - metabolism
Humans
metabolic disorders
mitochondria
Mitochondria - metabolism
mitochondrial biomarkers and therapies
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Summary:Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two global epidemics that share several metabolic defects, such as insulin resistance, impaired glucose metabolism, and mitochondrial defects. Importantly, strong evidence demonstrates that T2D significantly increases the risk of cognitive decline and dementia, particularly AD. Here, we provide an overview of the metabolic defects that characterize and link both pathologies putting the focus on mitochondria. The biomarker potential of mitochondrial components and the therapeutic potential of some drugs that target and modulate mitochondria are also briefly discussed. •Type 2 diabetes (T2D) is an important risk factor for Alzheimer's disease (AD).•Mitochondrial dysfunction is a shared feature between T2D and AD.•Mitochondrial components found in peripheral blood are potential biomarkers of neurodegeneration.•Mitochondria-targeted drugs have the potential to treat neurodegenerative conditions.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2023.102694