Cholesterol enhances the negative impact of vaping additives on lung surfactant model systems

Vaping has given rise to e-cigarette or vaping product use-associated lung injury. Model lung surfactant films were used to assess the impact of vape additives (vitamin E, vitamin E acetate, tetrahydrocannabinol, cannabidiol). This work builds upon our previous findings, by incorporating cholesterol...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2022-12, Vol.17 (30), p.2231-2243
Main Authors: Bavel, Nicolas Van, Lai, Patrick, Loebenberg, Raimar, Prenner, Elmar J
Format: Article
Language:English
Subjects:
biophysical characterization
Brewster angle microscopy
cannabinoids
Cholesterol
detrimental effects
Electronic Nicotine Delivery Systems
EVALI
Humans
Lung
Lung Injury - chemically induced
lung surfactant model system
monolayers at air–water interface
Surface-Active Agents
Vaping - adverse effects
vaping additives
Vitamin E
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Summary:Vaping has given rise to e-cigarette or vaping product use-associated lung injury. Model lung surfactant films were used to assess the impact of vape additives (vitamin E, vitamin E acetate, tetrahydrocannabinol, cannabidiol). This work builds upon our previous findings, by incorporating cholesterol, to understand the interplay between the additives and the sterol in surfactant function. Compression–expansion cycles of lipid monofilm at the air–water interface and Brewster angle microscopy allowed elucidating the effects of vape additives. Vape additives at 5 mol% inhibited proper lipid packing and reduced film stability. Cholesterol enhanced the additive effects, resulting in significantly destabilized films and altered domains. The observed impact could signify dysfunctional lung surfactant and impaired lung function.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2022-0232