Clinical characteristics and prognosis of pregnancy-related acute kidney injury: a case series study

Objective Acute kidney injury (AKI) seriously affects the health of both pregnant women and fetuses. This study aimed to investigate the clinical characteristics and prognosis of pregnancy-related AKI (PR-AKI). Methods This case series study enrolled pregnant women with PR-AKI admitted to the surgic...

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Bibliographic Details
Published in:International urology and nephrology 2023-09, Vol.55 (9), p.2249-2255
Main Authors: Lu, Wei, Hu, Min-Jie, Zhu, Dong-Dong, Lin, Fu-Jun, Huang, Hai-Dong
Format: Article
Language:English
Subjects:
Acute Kidney Injury - diagnosis
Acute Kidney Injury - epidemiology
Acute Kidney Injury - etiology
Adult
Asphyxia
Birth weight
China - epidemiology
Female
Fetuses
Hemoglobin
Humans
Infant
Infant, Newborn
Kidney
Kidneys
Low birth weight
Medicine
Medicine & Public Health
Neonates
Nephrology
Nephrology - Original Paper
Patients
Pregnancy
Pregnancy Outcome - epidemiology
Premature birth
Prognosis
Renal function
Retrospective Studies
Uric acid
Urology
Young Adult
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Summary:Objective Acute kidney injury (AKI) seriously affects the health of both pregnant women and fetuses. This study aimed to investigate the clinical characteristics and prognosis of pregnancy-related AKI (PR-AKI). Methods This case series study enrolled pregnant women with PR-AKI admitted to the surgical intensive care unit of Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine between January 2010 and December 2020. Results Thirty-one PR-AKI patients were enrolled with a mean age of 29.16 ± 4.97 years. Seventeen pregnant women (54.84%) had complete recovery of renal function, 5 (16.13%) had partial recovery of renal function, 2 (6.45%) patients had no renal function improvement, and 7 (22.58%) died. Among the 31 patients with 35 fetuses, 25 (80.6%) pregnant women had poor fetal outcomes, including 5 cases of stillbirths, 5 neonatal asphyxia, 18 premature births, 10 low birth weight, and 8 deficient birth weight infants. Compared to cases with good fetal outcomes, cases with poor fetal outcomes had significantly shorter gestational weeks (39.26 ± 1.53 vs. 31.62 ± 5.50, P  = 0.002), lower platelet count (217.13 ± 122.87 vs. 90.24 ± 84.88, P  = 0.005), lower hemoglobin (94.19 ± 13.21 vs. 74.48 ± 20.78, P  = 0.036), higher blood urea nitrogen (11.87 ± 4.28 vs. 19.47 ± 10.98, P  = 0.013), and higher uric acid (262.41 ± 167.00 vs. 586.87 ± 144.52, P  
ISSN:1573-2584
0301-1623
1573-2584
DOI:10.1007/s11255-023-03484-6