Characteristics and health risk assessment of volatile N-nitrosamines in the plasma of adults in Guangdong Province, China

N-nitrosamines are strong carcinogens that are widely present in the environment. This study developed a method, and analyzed the concentrations of volatile N-nitrosamines (VNAs) in the plasma of adults in Guangdong Province, China. Finally, the health risks to adults in Guangdong Province, China, w...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2023-04, Vol.227, p.115189-115189, Article 115189
Main Authors: Lin, Simin, Wang, Hetao, Cai, Lishan, Liao, Lili, Su, Yintong, Cai, Xiaohua, Shen, Mei
Format: Article
Language:English
Subjects:
Adult
China
Exposure levels
Human plasma
Humans
Nitrosamines - analysis
Reproducibility of Results
Risk Assessment
Volatile N-nitrosamines
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Summary:N-nitrosamines are strong carcinogens that are widely present in the environment. This study developed a method, and analyzed the concentrations of volatile N-nitrosamines (VNAs) in the plasma of adults in Guangdong Province, China. Finally, the health risks to adults in Guangdong Province, China, with dietary exposure to VNAs were assessed. Gas chromatography/mass spectrometry (GC/MS) in electron impact (EI) ionization source mode was used to quantitatively analyze VNAs, and to perform accurate mass determination. The lower limit of detection (LOD) of nine nitrosamines are ranged from 0.01 to 2.14 ng/mL. The recovery rate ranged from 83 % to 116 %, and the relative standard deviation (RSD) was
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2022.115189