TCR-signals downstream adversely correlate with the survival signals of memory CD8+ T cells under homeostasis

The significance of self-peptide-MHC-I/TCR (SMT) interaction in the survival of CD8+ T cells during naïve- and developmental-stages is well documented. However, the same for the memory stage is contentious. Previous studies have attempted to address the issue using MHC-I or TCR deficient systems, bu...

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Published in:Immunobiology (1979) 2023-05, Vol.228 (3), p.152354-152354, Article 152354
Main Authors: Yadav, Naveen, Patel, Hardik, Parmar, Rajesh, Patidar, Manoj, Dalai, Sarat K.
Format: Article
Language:English
Subjects:
Animals
Annexin-V
Antigens - metabolism
Bcl-2
CD8-Positive T-Lymphocytes
Homeostasis
Ki-67
Lymphocyte Activation
Memory CD8+ T cell
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nur77
Receptors, Antigen, T-Cell - metabolism
Self-peptide-MHC-I/TCR interaction
TCR signal
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Summary:The significance of self-peptide-MHC-I/TCR (SMT) interaction in the survival of CD8+ T cells during naïve- and developmental-stages is well documented. However, the same for the memory stage is contentious. Previous studies have attempted to address the issue using MHC-I or TCR deficient systems, but inconsistent findings with memory CD8+ T cells of different TCR specificities have complicated the interpretation. Differential presence and/or processing of TCR-signals downstream in memory CD8+ T cells of different TCR specificities could be thought of as a reason. In this study, we examined the TCR-signals downstream in memory CD8+ T cells and compared them to the presence of survival-related signals (Annexin-V, Bcl-2, and Ki-67). We categorically tracked foreign antigen-experienced memory CD8+ T (TM) cells generated after Plasmodium pre-erythrocytic-stage malaria infection in C57BL/6 mice. Interestingly, we found that memory CD8+ T cells had more TCR-signals downstream than naive cells. We reasoned and attributed the increased expression of cell adhesion molecules to the enhanced TCR-signaling. TCR-signals downstream correlate more closely with survival signals in naive CD8+ T cells than with death signals in TM cells. Further investigation using antigen-specific CD8+ T cells and diverse infection systems would aid in conceptualizing the findings.
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2023.152354