Administration of growth hormone ameliorates adverse effects of total sleep deprivation

Total sleep deprivation (TSD) causes several harmful changes including anxiety, inflammation, and increased expression of extracellular signal-regulated kinase (ERK) and tropomyosin receptor kinase B (TrkB) genes in the hippocampus. The current study was conducted to explain the possible effects of...

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Bibliographic Details
Published in:Metabolic brain disease 2023-06, Vol.38 (5), p.1671-1681
Main Authors: Arvin, Parisa, Ghafouri, Samireh, Bavarsad, Kowsar, Hajipour, Somayeh, Khoshnam, Seyed Esmaeil, Sarkaki, Alireza, Farbood, Yaghoub
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Coordination
Corticotropin-Releasing Hormone
Cytokines
Extracellular signal-regulated kinase
Genes
Growth Hormone
Growth hormones
Hippocampus
Inflammation
Interleukin 4
Interleukin 6
Kinases
Locomotion
Male
Metabolic Diseases
Motor ability
Neurology
Neurosciences
Oncology
Original Article
Rats
Rats, Wistar
Sleep deprivation
Sleep Deprivation - complications
Sleep Deprivation - drug therapy
TrkB receptors
Tropomyosin
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Summary:Total sleep deprivation (TSD) causes several harmful changes including anxiety, inflammation, and increased expression of extracellular signal-regulated kinase (ERK) and tropomyosin receptor kinase B (TrkB) genes in the hippocampus. The current study was conducted to explain the possible effects of exogenous GH against the above parameters caused by TSD and the possible mechanisms involved. Male Wistar rats were divided into 1) control, 2) TSD and 3) TSD + GH groups. To induce TSD, the rats received a mild repetitive electric shock (2 mA, 3 s) to their paws every 10 min for 21 days. Rats in the third group received GH (1 ml/kg, sc) for 21 days as treatment for TSD. The motor coordination, locomotion, the level of IL-6, and expression of ERK and TrkB genes in hippocampal tissue were measured after TSD. The motor coordination (p 
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-023-01192-9