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Comparison of PD-L1 and VISTA expression status in primary and recurrent/refractory tissue after (chemo)radiotherapy in head and neck cancer

Background PD-L1 and VISTA are thought to play a role in escape from the immune system, tumor progression, and treatment response in tumoral tissue. The current study aimed to evaluate the effects of radiotherapy (RT) and chemoradiotherapy (CRT) on PD-L1 and VISTA expression in head and neck cancers...

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Published in:Strahlentherapie und Onkologie 2023-08, Vol.199 (8), p.761-772
Main Authors: Şener, Görkem Yazıcı, Sütcüoğlu, Osman, Öğüt, Betül, Güven, Deniz Can, Kavuncuoğlu, Altan, Özdemir, Nuriye, Özet, Ahmet, Aksoy, Sercan, Tezel, Yeşim Gaye Güler, Akyürek, Nalan, Yazıcı, Ozan
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Language:English
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Summary:Background PD-L1 and VISTA are thought to play a role in escape from the immune system, tumor progression, and treatment response in tumoral tissue. The current study aimed to evaluate the effects of radiotherapy (RT) and chemoradiotherapy (CRT) on PD-L1 and VISTA expression in head and neck cancers. Methods PD-L1 and VISTA expression were compared between the primary biopsy taken at the time of diagnosis and refractory tissue biopsies of patients who received definitive CRT or recurrent tissue biopsies of patients who had surgery followed by adjuvant RT or CRT. Results In total, 47 patients were included. Radiotherapy had no effect on the expression levels of PD-L1 and VISTA in patients with head and neck cancer ( p  = 0.542 and p  = 0.425, respectively). A positive correlation was found between PD-L1 and VISTA expression ( p  
ISSN:0179-7158
1439-099X
DOI:10.1007/s00066-023-02053-1