Vancomycin-resistant Enterococcus faecium and the emergence of new sequence types associated with hospital infection

Enterococcus faecium is a major species in infections by vancomycin-resistant enterococci (VRE). New variants of the pathogen have emerged and become dominant in healthcare settings. Two such examples, vanB ST796 and vanA ST1421 sequence types, originally arose in Australia and proceeded to cause VR...

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Bibliographic Details
Published in:Research in microbiology 2023-05, Vol.174 (4), p.104046-104046, Article 104046
Main Authors: O'Toole, Ronan F., Leong, Kelvin W.C., Cumming, Vanessa, Van Hal, Sebastiaan J.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Bacterial Proteins - genetics
Cross Infection
Enterococcus faecium - genetics
Enterococcus faecium: antibiotic resistance
Gram-Positive Bacterial Infections
Humans
Microbial Sensitivity Tests
Multi-locus sequence typing
Vancomycin
Vancomycin - pharmacology
Vancomycin-Resistant Enterococci - genetics
Whole genome sequencing
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Summary:Enterococcus faecium is a major species in infections by vancomycin-resistant enterococci (VRE). New variants of the pathogen have emerged and become dominant in healthcare settings. Two such examples, vanB ST796 and vanA ST1421 sequence types, originally arose in Australia and proceeded to cause VRE outbreaks in other countries. Of concern is the detection in Europe of vancomycin variable enterococci (VVE) belonging to ST1421 that exhibit a vancomycin-susceptible phenotype but can revert to resistant in the presence of vancomycin. The recent application of genome sequencing for increasing our understanding of the evolution and spread of VRE is also explored here.
ISSN:0923-2508
1769-7123
DOI:10.1016/j.resmic.2023.104046