Association Between Serum Copper Levels and Urinary Incontinence in Adult Men

Urinary incontinence (UI) is a major health burden to aging patients. The function of the trace element copper in male UI is unclear. To elaborate on the impact of serum copper levels on UI, we investigated the association between serum copper levels and UI using data from the National Health and Nu...

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Bibliographic Details
Published in:Biological trace element research 2023-12, Vol.201 (12), p.5521-5528
Main Authors: Liu, Guo-Dao, Wang, Wei-Guo, Dai, Chao, Cai, Chun-Jie, Hu, Qin
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biotechnology
Copper
Life Sciences
Males
Nutrition
Oncology
Regression analysis
Regression models
Serum
Statistical analysis
Surveys
Trace elements
Trace elements (nutrients)
Urinary incontinence
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Summary:Urinary incontinence (UI) is a major health burden to aging patients. The function of the trace element copper in male UI is unclear. To elaborate on the impact of serum copper levels on UI, we investigated the association between serum copper levels and UI using data from the National Health and Nutrition Examination Survey (NHANES), a cross-sectional survey of male participants aged 20 years old and older in the United States from 2011 to 2016. We performed weighted multivariable logistic and linear regression models to evaluate the association between serum copper levels and UI. Compared with serum copper levels in quartile 1 (Q1), serum copper levels in Q2 and Q3 were associated with stress urinary incontinence (SUI) after adjusting for all potential confounders (Q2, odds ratio [OR] = 0.292, 95% confidence interval [CI] = 0.093–0.920, P  = 0.047; Q3, OR = 0.326, 95% CI = 0.113–0.937, P  = 0.049). No significance was found between serum copper levels and other types of UI. Our findings revealed that the serum copper levels were inversely related to SUI in adult males. Race and education level might modulate this relationship. Further studies are warranted for validation.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-023-03613-3