Prognostic factors and outcomes of adult spermatic cord sarcoma. A study from the French Sarcoma Group

To evaluate the outcomes of adult patients with spermatic cord sarcoma (SCS). All consecutive patients with SCS managed by the French Sarcoma Group from 1980 to 2017 were analysed retrospectively. Multivariate analysis (MVA) was used to identify independent correlates of overall survival (OS), metas...

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Published in:European journal of surgical oncology 2023-07, Vol.49 (7), p.1203-1208
Main Authors: Achard, Gilles, Charon-Barra, Céline, Carrere, Sebastien, Bonvalot, Sylvie, Meeus, Pierre, Fau, Magali, Honoré, Charles, Delhorme, Jean-Baptiste, Tzanis, Dimitri, Le Loarer, François, Karanian-Philippe, Marie, Ngo, Carine, Le Guellec, Sophie, Bertaut, Aurélie, Causeret, Sylvain, Isambert, Nicolas
Format: Article
Language:English
Subjects:
Adult
Aged
Humans
Leiomyosarcoma - pathology
Lipopolysaccharides
Liposarcoma - diagnosis
Liposarcoma - surgery
Male
Neoplasm Recurrence, Local - pathology
Prognosis
Retrospective Studies
Sarcoma - surgery
Sarcoma unplained excision
Soft Tissue Neoplasms
Spermatic Cord - pathology
Spermatic cord sarcoma
Surgery
Treatment
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Summary:To evaluate the outcomes of adult patients with spermatic cord sarcoma (SCS). All consecutive patients with SCS managed by the French Sarcoma Group from 1980 to 2017 were analysed retrospectively. Multivariate analysis (MVA) was used to identify independent correlates of overall survival (OS), metastasis-free survival (MFS), and local relapse-free survival (LRFS). A total of 224 patients were recorded. The median age was 65.1 years. Forty-one (20.1%) SCSs were discovered unexpectedly during inguinal hernia surgery. The most common subtypes were liposarcoma (LPS) (73%) and leiomyosarcoma (LMS) (12.5%). The initial treatment was surgery for 218 (97.3%) patients. Forty-two patients (18.8%) received radiotherapy, 17 patients (7.6%) received chemotherapy. The median follow-up was 5.1 years. The median OS was 13.9 years. In MVA, OS decreased significantly with histology (HR, well-differentiated LPS versus others = 0.096; p = 0.0224), high grade (HR, 3 versus 1–2 = 2.7; p = 0.0111), previous cancer and metastasis at diagnosis (HR = 6.8; p = 0.0006). The five-year MFS was 85.9% [95% CI: 79.3–90.6]. In MVA, significant factors associated with MFS were LMS subtype (HR = 4.517; p 
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2023.02.013